Tetrabutylammonium Fluoride

Duxiu Chemical

Specifications

HS Code	285562
Chemical Formula	C16H36FN
Molar Mass	261.46 g/mol
Appearance	Colorless to pale yellow liquid
Solubility	Soluble in water, alcohols, ethers, and many organic solvents
Melting Point	Approximately -20 °C
Boiling Point	Decomposes before boiling
Density	0.96 g/cm³ (20 °C)
Ph Aqueous Solution	Basic
Flash Point	Approximately 30 °C
Storage Conditions	Stored in a cool, dry, well - ventilated place away from oxidizing agents

Packing & Storage

Packing	100 - gram bottle of Tetrabutylammonium Fluoride, securely sealed for chemical use.
Storage	Tetrabutylammonium fluoride should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption, as it is hygroscopic. Store separately from incompatible substances like oxidizing agents and acids to avoid potential chemical reactions. Adhere to safety regulations during storage for risk - free handling.
Shipping	Tetrabutylammonium fluoride is a chemical often shipped in sealed, corrosion - resistant containers. Due to its reactivity, it's carefully packaged to prevent leakage during transit, following strict chemical shipping regulations.

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General Information

Historical Development

"Historical Biography of Tetrabutylammonium Fluoride"
Tetrabutylammonium fluoride is a wonder of chemistry. At the beginning, the academic community deepened its research and revealed its true face. At the beginning, in the laboratory, various sages studied the wonders of physical properties and reactions.
At that time, science and technology were not as prosperous as they are today, and the road of inquiry was full of thorns. However, the public worked tirelessly and tried repeatedly to finally understand its characteristics. It can show its skills in organic synthesis and help the reaction, and gradually becomes the most important thing in the academic community.
With the passage of time, the process is becoming more and more mature, and its application is also wide. In the fields of medicine and materials, it has its own merits. The difficulties of the past have been turned into the benefits of the present, contributing to the development of chemistry, and shining brightly. Future generations should also remember the achievements of various sages in exploration.

Product Overview

"Overview of Tetrabutylammonium Fluoride Products"
Tetrabutylammonium fluoride is unique among chemical substances. Its shape is either liquid or solid. Looking at its molecular structure, the tetrabutylammonium cation is coordinated with the fluorine anion, resulting in its specific chemical behavior.
In the field of organic synthesis, tetrabutylammonium fluoride has a wide range of uses. It can be used as a desilication reagent to help remove the silicon protective group, so that the organic synthesis step is smooth and the expected product can be obtained. It also has good effect in the phase transfer catalytic reaction, which can increase the reaction rate and increase the yield.
The preparation of this product requires a precise chemical process. The proportion of reactants and the control of reaction conditions are all related to product quality. And when storing, it is appropriate to avoid moisture and heat, and keep its chemical properties stable, so that it can be used and show its due effect.

Physical & Chemical Properties

Tetrabutylammonium fluoride (Tetrabutylammonium Fluoride) is a commonly used reagent in organic synthesis. Its physical and chemical properties are particularly important. Looking at its physical properties, it is mostly white crystals or powders at room temperature, with certain solubility, and can be well dissolved in organic solvents such as acetonitrile and tetrahydrofuran. This property facilitates its effectiveness in various reaction systems.
In terms of its chemical properties, the fluoride ion in tetrabutylammonium fluoride is nucleophilic and can participate in many nucleophilic substitution reactions. And its cationic part, tetrabutylammonium ion, has the function of phase transfer catalysis, which can promote the efficient reaction in two-phase systems. Due to its unique physical and chemical properties, in the field of organic synthesis, reactions such as the removal of silicon ether protecting groups are often relied on by this reagent to achieve the desired chemical transformation, which has contributed significantly to the development of organic synthetic chemistry.

Technical Specifications & Labeling

"Technical Specifications and Labeling (Product Parameters) of Tetrabutylammonium Fluoride"
Tetrabutylammonium fluoride is quite important in the field of chemical industry. Its technical specifications, the first purity, must reach a very high accuracy, with very few impurities. Its color state should be a colorless to slightly yellow transparent liquid with no foreign matter mixed in it.
On the logo, the product parameters are clear. The content is mostly indicated by an accurate number. For example, the proportion of tetrabutylammonium fluoride contained must be clearly marked. And on the packaging, the warning label is indispensable because it has certain chemical activity and is related to safety. There are also storage regulations, suitable for cool, dry places, avoiding heat and moisture, so as to ensure its stable quality and meet the needs of various chemical applications.

Preparation Method

The method of making tetrabutylammonium fluoride is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials are often tetrabutyl ammonium salt and fluoride-containing compounds. First, the tetrabutyl ammonium salt is dissolved in a suitable solvent, and then fluoride is slowly added to react at a specific temperature and pressure. In the reaction step, the reaction time and rate need to be carefully controlled, and it can be fully contacted and reacted by stirring. In the catalytic mechanism, or a specific catalyst can be added to reduce the activation energy of the reaction and speed up the process. In this way, high-purity tetrabutylammonium fluoride products can be obtained through subsequent processes such as refining and purification.

Chemical Reactions & Modifications

Nowadays, there is a chemical substance called Tetrabutylammonium Fluoride. In the field of chemistry, its reaction and modification are of great importance to scholars.
This agent is often used as a fluorination reagent in the context of organic synthesis. During the reaction, the substrate can obtain fluorine atoms and form a different structure. However, its nature also needs to be investigated in detail. At first, its reactivity may not be sufficient, and under specific circumstances, it is difficult to achieve the expected results.
Later, the researchers studied diligently, and after many tests, adjusted the reaction conditions, such as temperature control, solvent selection, etc. To get good results, its reactivity was greatly increased, and the selectivity was better. The modification of this agent has added a powerful tool to chemical synthesis, and it has been used in the fields of medicine and materials, contributing to the progress of chemistry.

Synonyms & Product Names

Today there is a thing called Tetrabutylammonium Fluoride. Although its names are different, they also have many synonyms. This chemical thing may have other commodity names in the industry.
The name of the husband is synonymous, so it is called also. The Jews used different names to represent the same thing. Tetrabutylammonium Fluoride, or another name to meet the needs of different users.
Its trade name is designed by merchants for other products. Like ancient trade names, each has its own name to honor its characteristics. Although the names are different, they all refer to this specific chemical. Its synonymous names and trade names are for the convenience of everyone to recognize and use this thing, so that all chemical things can be accurate and appropriate.

Safety & Operational Standards

Tetrabutylammonium fluoride (Tetrabutylammonium Fluoride) is also a chemical substance. It is widely used in the room and the work area. However, the safe operation of this substance cannot be ignored.
In terms of safety, tetrabutylammonium fluoride is dangerous to a certain extent. It can irritate the skin, eyes and respiratory tract. If you accidentally touch the skin, wash it with a lot of water immediately, and the situation will be cured. If it enters the eye, you need to wash it with a large amount of running water or physiological water immediately, that is, ask for it. And inhaling its steam may also cause the respiratory tract to malfunction. This speed will move to a good state. If the disease is severe, it must be damaged.
The operation is also very important. For the use of tetrabutyl fluoride, it is advisable to carry out it in the air to avoid evaporation and accumulation. The operator should wear appropriate anti-dumping equipment, such as clothing, gloves and eyewear. And after use, proper storage should not be ignored.
In addition, tetrabutyl fluoride is required for research and production. However, we must follow safe operating procedures to prevent accidental production and ensure personal and environmental safety.

Application Area

Nowadays, there is a name Tetrabutylammonium Fluoride, which has a wide range of uses. In the field of organic synthesis, it is often used as a fluorination reagent. It can guide fluorine atoms into organic molecules to form special structures, which is especially crucial in the creation of new compounds.
It is also indispensable in the process of desilicon protecting groups. Silicone compounds are often used to protect specific functional groups due to their stability. After the reaction is completed, Tetrabutylammonium Fluoride can gently deprotect the groups, so that the functional groups can regain their activity without disturbing other parts of the molecule.
It also exhibits unique performance in catalytic reactions. It can change the rate and path of chemical reactions, promote the efficient progress of reactions, and obtain high-purity products. From this point of view, Tetrabutylammonium Fluoride has important value in various chemical application fields and promotes the progress of chemical synthesis technology.

Research & Development

Nowadays, there is a chemical substance named Tetrabutylammonium Fluoride. My generation is a chemical researcher, and its research and development are quite concerned. This substance has unique properties and has great potential in organic synthesis and other fields.
We have studied its reaction mechanism and scope of application for a long time. Initially, many problems arose, such as harsh reaction conditions and poor yield. However, everyone worked tirelessly. After repeated experiments, we adjusted the temperature, solvent, catalyst and other factors.
Gradually gained, knowing the specific temperature and solvent combination can improve the reaction efficiency. It was also found that it can play a key catalytic role in some special reactions. Nowadays, Tetrabutylammonium Fluoride is being widely used, but there is still room for improvement. We will continue to study it to promote its better development and contribute to the field of chemistry.

Toxicity Research

The taste of chemical industry is related to people's livelihood, and the toxicity of things needs to be investigated in detail. Today there is Tetrabutylammonium Fluoride, and for us chemical researchers, the study of its toxicity should not be ignored.
The properties of this thing are occasionally touched during experiments. I first felt its pungent breath, smelled it for a long time, and felt a slight dizziness in my head. Or it is touched by the skin. If it is not quickly cleaned, it will sometimes itch and look like erythema.
Looking at ancient books, although there is no name for it, the reason for toxicity is the same. Poisons invade the body, either from the mouth and nose, or from the skin, and harm the organs and meridians. The same is true of Tetrabutylammonium Fluoride. Therefore, when researching, the protective equipment must be complete, and the operating regulations must be observed to prevent the harm of toxicity, protect my safety, and maintain the smooth progress of the research.

Future Prospects

Nowadays, there is a name Tetrabutylammonium Fluoride, which is widely used in the field of chemistry. Looking at its current situation, it has emerged in many aspects such as organic synthesis.
Looking to the future, Tetrabutylammonium Fluoride is expected to play a big role in the research and development of new materials. Due to the advance of science and technology, the demand for materials is becoming more and more diverse, and its unique properties may help new materials have better performance.
And in the field of catalytic reaction, there is also broad room for expansion. It may be possible to improve the catalytic efficiency and reduce the energy consumption of the reaction through optimization and improvement. In time, it will be able to shine and heat up in the chemical industry, adding to the future development and realizing more unfulfilled expectations.

Frequently Asked Questions

Common Uses of Tetrabutylammonium Fluoride

Tetrabutylammonium fluoride (Tetrabutylammonium Fluoride) is a commonly used reagent in organic synthesis. Its common uses are many.
It is extremely important to remove the silicon protective group. In organic synthesis, the silicon group is often used as a protective group to protect a specific functional group. When the reaction is completed, it needs to be removed. Tetrabutylammonium fluoride because of its strong silicophilicity of fluoride ions, can bind closely to silicon atoms, so that the silicon protective group can leave, achieve the purpose of deprotection, and help to form the target product.
And in the field of phase transfer catalysis, it also plays a key role. Due to its large volume and lipophilicity, the cationic part of tetrabutylammonium can dissolve fluoride ions in the organic phase, increase the transport and reaction between the aqueous phase and the organic phase, catalyze many two-phase reactions, such as nucleophilic substitution, and improve the reaction rate and yield.
Furthermore, in the synthesis of some fluorine-containing compounds, tetrabutylammonium fluoride can be used as a fluorine source. By providing fluoride ions, participating in fluorination reactions, forming fluorocarbon-fluorine bonds, fluorine-containing organic compounds with special properties are prepared, which are widely used in medicine, materials and other fields.
In some organometallic chemical-related reactions, it can affect the reactivity and selectivity of metal complexes. It interacts with the metal center to change its electron cloud density and spatial structure, thereby regulating the reaction process and realizing the efficient progress of specific organometallic reactions.

Tetrabutylammonium Fluoride is commonly used in which chemical reactions

Tetrabutylammonium fluoride is widely used in various chemical reactions. In the field of organic synthesis, it is often a fluorination reagent. It can guide fluorine atoms into organic molecules. Due to the unique electronic properties of fluorine atoms, fluorine-containing organisms have specific physical, chemical and biological properties, so it is useful in the creation of medicines and pesticides.
For example, in nucleophilic substitution reactions, tetrabutylammonium fluoride can replace halogens in halogenated hydrocarbons with fluorine. Due to the nucleophilicity of fluorine ions, tetrabutylammonium ions are used as phase transfer catalysts, which can make the reaction proceed smoothly in a two-phase system, increase the reactivity of fluoride ions, and improve the reaction rate and yield.
It is also common in the reaction of removing the protective group of silicon ether. Silicon ether often acts as a hydroxyl protecting group to protect the hydroxyl group from unnecessary reactions in the organic synthesis step. At the end of the reaction, to release the hydroxyl group, tetrabutylammonium fluoride can interact with the silicon ether to break the silicon ether bond and reproduce the hydroxyl group. This reagent has good selectivity and has little effect on other functional groups of the molecule.
In the synthesis of some fluorine-containing heterocyclic compounds, tetrabutylammonium fluoride can be used as a key reagent to help the ring reaction occur and construct the fluorine-containing heterocyclic structure, providing a way for the creation of new fluorine-containing compounds. Due to its effectiveness in fluorination and related reactions, it is important in the field of organic chemical synthesis.

What are the Physical Properties of Tetrabutylammonium Fluoride?

Tetrabutylammonium fluoride (Tetrabutylammonium Fluoride) is a commonly used reagent in organic chemistry. Its physical properties are quite unique.
Looking at its morphology, it is usually a white to yellowish solid at room temperature, or a colorless to yellowish liquid, depending on the specific purity and crystalline state. Its melting point and boiling point are also fixed, with a melting point between about 35-40 ° C, and the boiling point varies depending on specific conditions, but is roughly around 275 ° C.
In terms of solubility, tetrabutylammonium fluoride exhibits good solubility in organic solvents. Common organic solvents such as acetonitrile, dichloromethane, and tetrahydrofuran can dissolve it. This property makes it easy to disperse and participate in the reaction process in organic synthesis reactions. And it also has a certain solubility in water, because its molecular structure includes both hydrophobic butyl groups, hydrophilic ammonium ions and fluorine ions.
Furthermore, tetrabutyl ammonium fluoride is hygroscopic. Exposed to air, it is easy to absorb water, so it needs to be properly sealed when stored to prevent it from deteriorating due to moisture absorption and affecting the effect of subsequent experiments.
In addition, its density is also an important physical property, about 0.98 g/mL. This density data is of great reference value when it comes to solution preparation, reaction system measurement, etc., which helps to accurately control the amount of reaction materials, thereby improving the accuracy and reproducibility of the experiment.

What are the Chemical Properties of Tetrabutylammonium Fluoride

Tetrabutylammonium fluoride (Tetrabutylammonium Fluoride) is a commonly used reagent in organic chemistry. Its chemical properties are unique and it plays a key role in many chemical reactions.
This reagent has strong nucleophilicity. Fluoride itself is quite nucleophilic, and the existence of a large cation such as tetrabutylammonium ion can make fluoride ions have good solubility and activity in organic solvents, so that they can efficiently participate in nucleophilic substitution reactions. For example, in the nucleophilic substitution of halogenated hydrocarbons, fluoride ions in tetrabutylammonium fluoride can quickly attack the carbon atoms of halogenated hydrocarbons and replace halogen atoms to form fluorine-containing organic compounds.
Tetrabutylammonium fluoride is also alkaline. Although it is slightly weaker than some strong bases, its alkalinity can also trigger specific acid-base reactions. In some reaction systems, it can capture protons at specific locations in the substrate molecule and push the reaction in a specific direction, such as promoting intra-molecular cyclization reactions. By capturing protons, it promotes intra-molecular chemical bond rearrangement and cyclization.
At the same time, it is effective in phase transfer catalysis. Tetrabutylammonium ions have good surface activity, which can transfer fluorine ions from the aqueous phase to the organic phase, thus breaking the boundary between the aqueous phase and the organic phase, allowing reactants that were originally difficult to contact in different phases to react efficiently at the phase interface. For example, in some reactions involving inorganic fluorides and organic substrates, the reaction rate and yield can be greatly improved by the phase transfer catalysis of tetrabutylammonium fluoride.
Furthermore, it has the characteristics of selective removal of silicon ether protective groups. In organic synthesis, silicon ether is often used as a protective group for functional groups such as hydroxyl groups. Tetrabutylammonium fluoride can gently and selectively break the siloxy bond, remove the silicon ether protective group, and restore the activity of the hydroxyl group. It has little effect on other functional groups in the molecule, which is of great significance for the selective protection and deprotection of functional groups in the synthesis step of complex organic compounds.

What are the Storage Conditions for Tetrabutylammonium Fluoride?

Tetrabutylammonium fluoride (Tetrabutylammonium Fluoride) is also a genus of chemical agents. Its storage conditions are of paramount importance, related to the quality and use of the agent.
This agent should be stored in a cool, dry and well-ventilated place. In a cool place, it can inhibit its change due to heat. If the cover temperature is too high, it may cause the decomposition and deterioration of the ingredients, which will damage its chemistry and efficacy.
Dry place, avoid it from moisture. Tetrabutylammonium fluoride likes dryness, and the water-wet gas encounters it, or triggers reactions such as hydrolysis, destroying its structure and reducing its purity.
Well-ventilated, it can remove the filth in the storage place, and prevent the accumulation of harmful gases. If it is blocked in a place, the gas accumulation of the drug will not dissipate, which will not only endanger the human body, but also affect the drug itself due to changes in concentration.
And it must be stored separately from oxidizing agents, acids and other substances. These two categories meet with tetrabutylammonium fluoride, or cause a violent chemical reaction, causing the risk of explosion.
When storing, also pay attention to the sealing of the container. If the sealing is not good, the drug will come into contact with the air and be easily disturbed by oxygen and water vapor. Therefore, when storing tetrabutyl ammonium fluoride, it is necessary to abide by the rules of cool, dry and ventilated, strictly separate the storage rules, and re-seal the matter, so as to ensure that the quality of the drug remains unchanged, and it can be used to achieve its effect.