What is the chemical structure of phenylsulfonylfluoride?

Phenyl sulfonyl fluoride, if its chemical structure is described in the ancient text of "Tiangong Kaiwu", it can be said that this is an organic compound composed of phenyl group and sulfonyl fluoride group. The phenyl group is the group left after the benzene ring is removed from a hydrogen atom, with a six-membered ring-like conjugated structure, which is quite stable and aromatic. The sulfonyl fluoride group is formed by a sulfur atom connected to a dioxy atom and a fluorine atom. The sulfur atom is connected to the dioxy atom by a double bond, and then forms a single bond with the fluorine atom. This structure gives it a specific chemical activity. The phenyl group is connected to the sulfonyl fluoride group by a covalent bond, and the sulfur atom is connected to the carbon atom of the benzene ring, thus forming the overall structure of the phenyl sulfon This structure makes the compound show unique properties and uses in the fields of organic synthesis, biochemical research, etc. Because of its activity of sulfonyl fluoride, it can react with many groups containing active hydrogen, such as hydroxyl and amino groups. It is often used as a protease inhibitor in protein research. By virtue of its structure and protein enzyme activity checking point, it inhibits the activity of enzymes, thus helping to explore protein function and biochemical reaction mechanism.

What are the main uses of phenylsulfonylfluoride?

Phenyl sulfonyl fluoride (phenylsulfonylfluoride), which has a wide range of uses. In the field of biochemical research, it is a protease inhibitor, which can covalently bind to the serine residue at the check point of serine protease activity, effectively inhibit protease activity, thereby blocking its proteolysis. It is commonly used in studying the mechanism of protease action and exploring the interaction between enzymes and substrates to help researchers clarify protein metabolism and regulatory pathways.

In the field of pharmaceutical research and development, it is a potential drug lead compound. By modifying and modifying its structure, new drugs with specific biological activities and good efficacy and small side effects may be obtained. Because it can precisely inhibit specific proteases, it is of great significance in the development of drugs for protease-related diseases (such as inflammation, tumors, etc.).

In the field of chemical synthesis, phenyl sulfonyl fluoride is used as a sulfonylation reagent. Sulfonyl groups can be introduced into other compound molecules to construct organic compounds with special structures and properties, providing an effective way to synthesize new materials and functional molecules, and enriching the methods and strategies of organic synthesis chemistry.

phenylsulfonylfluoride what are the precautions during use

When using benzylsulfonyl fluoride (Phenylsulfonylfluoride), there are many precautions that need to be taken with caution.

The first priority is safety protection, which is the top priority. Benzylsulfonyl fluoride is toxic and corrosive, and must be fully armed when in contact with it. Wear protective clothing, protective gloves and goggles. If it accidentally stains the skin or gets into the eyes, rinse it with plenty of water immediately, and seek medical attention immediately. Don't delay the opportunity.

Furthermore, it is about its storage. Store benzylsulfonyl fluoride in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its active chemical nature, improper storage can easily cause deterioration or cause danger. And it should be stored separately from oxidants, acids, alkalis, etc., to avoid adverse reactions caused by mixed storage.

During use, accurate concentration control is essential. According to the specific needs of the experiment or production, accurately adjust the appropriate concentration. If the concentration is too high, it may cause an overreaction and damage the target substance; if the concentration is too low, it will be difficult to achieve the expected effect.

In addition, the operating environment should not be ignored. Relevant operations should be carried out in the fume hood to discharge volatile gases in time to reduce the concentration of harmful substances in the air and ensure the safety of operators. After the operation is completed, the equipment used should be properly cleaned and handled to prevent residual substances from polluting subsequent experiments or production.

Furthermore, the solubility characteristics of benzylsulfonyl fluoride need to be paid attention to. It has good solubility in some organic solvents. When using it, choose a suitable solvent according to its characteristics to ensure that it is fully dissolved and evenly dispersed to exert the best effect.

In short, the use of benzylsulfonyl fluoride requires careful consideration from various aspects such as safety protection, storage, concentration control, and operating environment, and careful operation to ensure smooth experimentation or production and avoid risks.

What is the preparation method of phenylsulfonylfluoride?

Phenylsulfonyl fluoride (phenylsulfonylfluoride), which is an important reagent in organic synthesis, has special chemical properties and is widely used in biochemical research and other fields. Its preparation methods are as follows.

One of the common preparation methods is to use thiophenol as the starting material. First, thiophenol is reacted with appropriate oxidants, such as hydrogen peroxide or m-chloroperoxybenzoic acid. This oxidation process can oxidize the sulfur atom in thiophenol to a high valence state. After oxidation, the intermediate of benzenesulfonic acid is formed. Subsequently, the benzenesulfonic acid is reacted with halogenated reagents, such as trifluoromethanesulfonic anhydride or oxalyl chloride. In this reaction step, the hydroxyl group in the benzenesulfonic acid can be converted into a halogen atom, and then the corresponding halogenated benzenesulfonic Finally, with the participation of suitable fluorinating reagents, such as potassium fluoride or tetrabutylammonium fluoride, the halogen atom is replaced by the fluorine atom to obtain phenylsulfonyl fluoride.

Another preparation method is to use benzenesulfonyl chloride as the starting material. First, benzenesulfonyl chloride is reacted with anhydrous hydrogen fluoride under specific conditions. This reaction requires careful control of temperature and reaction time, because anhydrous hydrogen fluoride is highly corrosive and toxic. During this process, the chlorine atom is gradually replaced by the fluorine atom, and phenylsulfonyl fluoride can be obtained after careful separation and purification.

When preparing phenylsulfonyl fluoride, the raw materials and reagents used are toxic, corrosive or dangerous, so the experimental operation must be carried out under strict safety protection conditions. And after each step of the reaction, recrystallization, distillation, column chromatography and other purification methods are needed to obtain high-purity phenyl sulfonyl fluoride products.

What is the market price range for phenylsulfonylfluoride?

Phenyl sulfonyl fluoride is also a chemical agent. The price range of its market varies depending on the quality, the quantity, and the change in supply and demand.

In terms of quality, when the quantity is small, the price per gram or tens of gold. If you use all kinds of research, the quality is fine, regardless of the cost, the price is also subject to high prices. If the quantity is wide, the business is to expand sales, or reduce its price, buy in batches, or reduce it to a few gold per gram.

And the way of purchase is different, and the price is also different. In the case of specializing agents, the price may be slightly higher due to the stability of their quality and supply. And from the market of ordinary chemical materials, or those who are cheap, the stability of the quality is unknown.

And the situation changes, the supply exceeds the demand, and the price decreases; if the demand exceeds the supply, the price will rise. It is based on the market price of phenylsulfonyl fluoride, which is roughly several gold to dozens of gold per gram. The actual price should be based on the current market conditions, the quantity and quality of purchases.