What are the main uses of p-Fluorobenzotrifluoride?

P-Fluorobenzotrifluoride, or p-fluorotoluene, is an important compound in organic chemistry and has a wide range of uses in many fields.

First, in the field of medicinal chemistry, it is a key intermediate. Due to its special chemical structure, fluorine atoms and trifluoromethyl give molecules unique physical and chemical properties, such as enhancing lipophilicity and improving metabolic stability. Using this as raw material, chemists can build complex drug molecular skeletons and develop new drugs. For example, in the development of anti-depressant and anti-tumor drugs, p-fluorotoluene is often used as a starting material. After multi-step reactions, other active groups are introduced to optimize drug activity and selectivity to meet clinical needs.

Second, in the field of materials science, it also plays an important role. It can be used as a monomer for synthesizing special polymer materials. The synthesized materials have excellent chemical stability, weather resistance and low surface energy due to the presence of fluorine atoms and trifluoromethyl. Such as the preparation of high-performance coatings and fluorinated plastics, such materials are widely used in aerospace, electronics industry and other fields. In aerospace, this type of material is used to make aircraft skins and engine parts, which can resist harsh environmental erosion; in the electronics industry, it is used to make printed circuit boards and electronic packaging materials to improve the electrical properties and chemical stability of materials.

Third, in the field of pesticide chemistry, p-fluorotrifluorotoluene is an important raw material for synthesizing high-efficiency pesticides. Using its structural characteristics, pesticides with high activity, low toxicity and good environmental compatibility can be developed. For example, new insecticides and fungicides can precisely target specific pests or pathogens, improve control effects, reduce the impact on the environment and non-target organisms, and contribute to sustainable agricultural development.

What are the physical properties of p-Fluorobenzotrifluoride?

P - Fluorobenzotrifluoride, Chinese name p-fluorotrifluorotoluene, is an important compound in organic chemistry. Its physical properties are as follows:

Viewed, this substance is a colorless and transparent liquid at room temperature and pressure, clear and clear, as pure as jade dew. It has a special smell, and its unique smell can be sensed by sniffing.

As far as the boiling point is concerned, it is about 102-103 ° C. At this temperature, the liquid turns into a gaseous state, similar to a rising state. This boiling point determines its physical state transition under a specific temperature environment, and is extremely critical in chemical operations such as separation and purification.

The melting point is about -48 ° C. When the temperature drops below this point, the originally flowing liquid will solidify into a solid state, like a sleeping crystal block. This melting point characteristic needs to be taken into account during storage and transportation, and it is related to the maintenance of its shape.

Its density is 1.327 g/mL (25 ° C), which is heavier than water. If placed in one place with water, it will sink to the bottom of the water, just like heavy objects sink. This density property is of guiding significance for the operation of layering and separation of substances in the operation of mixed systems.

In addition, its solubility also has characteristics. Slightly soluble in water, it is like an isolated individual in water, and it is difficult to blend with water. However, it can be soluble in most organic solvents, such as alcohols, ethers, ketones, etc., and can be uniformly dispersed in these organic solvents, like a duck to water. This difference in solubility provides a basis for the selection of solvents for organic synthesis reactions. Different reactions choose suitable solvents according to their needs to achieve the best reaction effect.

Its vapor pressure has a specific value at a certain temperature, which affects its volatilization degree. The higher the vapor pressure, the faster the volatilization. It has an impact on ventilation, storage environment, etc. It needs to be properly handled to prevent volatilization from causing safety hazards or material loss. The above physical properties play an important role in many fields such as chemical production, organic synthesis, storage and transportation. Only by accurately grasping them can this compound be used rationally in various fields.

Is p-Fluorobenzotrifluoride chemically stable?

P-Fluorobenzotrifluoride, the chemical compound of the formula\ (C_ {7} H_ {4} F_ {4}\) also has certain properties. Because of the presence of fluorine atoms and trifluoromethyl in the molecule, the molecular force is changed, and the carbon-fluorine energy is high.

In other words, fluorine atoms on aromatics have some activity, but compared with other atoms, their nuclei often need special components such as nuclear substitution. This is because the fluorine atom has high performance, the co-effect of benzene formation reduces the density of aromatics, and the carbon-fluorine is short, so the general fluorine nuclei can easily replace fluorine atoms.

The existence of trifluoromethyl also affects the molecular properties. It reduces the density of benzene molecules further, so that the replacement of aromatics can be generated. Moreover, the immediate effect of trifluoromethyl cannot be ignored, and it affects the empty image and the orientation of the molecule.

Furthermore, the physical rationality of p-Fluorobenzotrifluoride also reflects the stability of its transformation. Its physical properties such as boiling and melting are often affected by molecular forces and qualitative effects. Usually, it has a certain degree of stability, but because of the molecular phase, it is not easy to decompose or produce strong reactions under normal circumstances.

In other words, p-Fluorobenzotrifluoride due to the special properties of the fluorine atom in the molecule, trifluoromethyl, its chemical properties are characterized by the chemical phase. Under the normal chemical reaction, the phase is not easy to be biodegraded.

What are the preparation methods of p-Fluorobenzotrifluoride?

There are several common methods for preparing p-fluorotoluene (p-Fluorobenzotrifluoride):
First, p-chlorotrifluorotoluene is used as the starting material and reacts with potassium fluoride under specific conditions. This reaction needs to be carried out in an organic solvent, such as N-methylpyrrolidone (NMP), etc. The reaction temperature is usually controlled in a high range, about 150-250 ° C. The principle is that fluorine ions replace chlorine atoms and undergo nucleophilic substitution. The chemical reaction formula is: $C_7H_4ClF_3 + KF\ stackrel {organic solvent, 150-250 ° C} {\ longrightarrow} C_7H_4F_4 + KCl $. The advantage of this method is that the raw materials are relatively easy to obtain and the reaction route is relatively direct; however, its disadvantages are also obvious. The reaction conditions are relatively harsh, high temperature and specific organic solvents are required, and the activity of potassium fluoride needs to be carefully controlled, otherwise the yield will be affected.
Second, p-fluorobenzoic acid is used as the starting material and prepared by multi-step reaction. First, p-fluorobenzoic acid is reacted with thionyl chloride to convert it into p-fluorobenzoyl chloride. The chemical reaction formula is: $C_7H_5FO_2 + SOCl_2\ longrightarrow C_7H_4FOCl + SO_2 + HCl $. Subsequently, p-fluorobenzoyl chloride reacts with reagents such as hydrogen fluoride and antimony fluoride to realize the trifluoromethylation process. There are a few more steps in this route, but the reaction conditions of each step are relatively mild, the yield is relatively considerable, and the requirements for reaction equipment are relatively low, which is easier to operate and control in industrial production.
Third, using benzene as raw material, selective fluorination is first carried out to generate p-fluorobenzene, and then trifluoromethyl is introduced. Selective fluorination often uses special catalysts, such as a catalytic system composed of fluorine-containing metal salts and specific ligands. The introduction of trifluoromethyl can utilize trifluoromethylation reagents, such as trifluoromethyl magnesium halide. Although the raw material cost of this method is low, the selective fluorination step is more difficult, and the reaction conditions need to be precisely controlled to ensure the high selectivity of p-fluorobenzene, otherwise there are many by-products, which will affect

What is the price range of p-Fluorobenzotrifluoride in the market?

Alas! If you want to know the quality of the p-Fluorobenzotrifluoride market, this matter is not easy. The use of this compound is not easy, and it is useful in the fields of chemical industry, engineering, and materials. Its price depends on factors such as product quality, supply and demand, production and production, production and production.

In the past, if the product was ordinary and the quantity was small, the price per gram was 10 yuan. However, if the product was excellent, the supply was not enough, and the price was 10 liters. And the large-scale mold work is not enough, because the quantity is large, the price per gram may be reduced to 10 yuan.

In the near future, if the self-generalization is small, the price may be between 30 yuan and 80 yuan per gram. If a large amount of production is required, the cost per kilogram may be less than 1,000 yuan, or about ten to thirty yuan per gram.

But the market is like an illusion, and the supply and demand change is easy. The emergence of new industry may also reduce the cost and reduce the price. Therefore, if you want to get the best price, you can get the best price.