Benzenesulfonyl Fluoride

Duxiu Chemical

Specifications

HS Code	817638
Name	Benzenesulfonyl Fluoride
Chemical Formula	C6H5SO2F
Molar Mass	160.165 g/mol
Appearance	Colorless to light yellow liquid
Odor	Pungent odor
Density	1.32 g/cm³
Boiling Point	208 - 210 °C
Melting Point	−26 °C
Solubility In Water	Reacts with water
Solubility In Organic Solvents	Soluble in many organic solvents
Flash Point	88 °C
Vapor Pressure	Low vapor pressure

As an accredited Benzenesulfonyl Fluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 - gram bottle packaging for Benzenesulfonyl Fluoride chemical.
Storage	Storage of Benzenesulfonyl Fluoride Benzenesulfonyl fluoride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances like strong oxidizers, bases, and reducing agents. Store it in a tightly - sealed container, preferably in a dedicated chemical storage cabinet, to prevent leakage and exposure.
Shipping	Benzenesulfonyl fluoride is a hazardous chemical. It should be shipped in accordance with strict regulations, using specialized containers to prevent leakage. Shipment must follow safety protocols for handling and transporting toxic substances.

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General Information

Historical Development

Benzenesulfonyl fluoride is also a chemical product. Tracing back to its origin, the academic community did not know its properties at the beginning. After years of research by various sages, its quality and use have gradually become clear. In the past, the road of exploration was painstakingly prepared, and everyone worked hard to observe its reaction rules and analyze its structure.
Over the years, the technology is new, and in the preparation of benzenesulfonyl fluoride, it has become more and more delicate. Its application has also become more and more extensive, in the field of biochemistry, assisting scientific research; in the field of industry, it has unique achievements. Since its inception, benzenesulfonyl fluoride has evolved with science and technology, continuously expanding its capabilities, adding luster to a corner of chemistry, and the prospect is becoming more and more clear. The future development can still be expected.

Product Overview

Benzenesulfonyl fluoride is an organic compound. It may be a colorless liquid with a specific odor. This substance is widely used in the field of chemical research. It is often used as an enzyme inhibitor, which can combine with the activity check point of enzymes to block their catalytic reactions. In biochemical experiments, research assistants explore the mechanism of enzymes.
Preparation method, or obtained by the reaction of benzenesulfonic acid and fluorinating agent. However, when preparing, it should be handled with caution, because it is toxic and corrosive to a certain extent.
When storing, it should be placed in a cool, dry and well-ventilated place to avoid contact with water and alkali substances to prevent deterioration. Those who use it should follow strict operating procedures and wear protective equipment to ensure their own safety and the purity of the experimental environment.

Physical & Chemical Properties

Benzenesulfonyl fluoride is also a chemical substance. Its quality is physical and chemical, and it is related to many uses. Looking at its physics, under room temperature, it may be liquid, color or light, and taste may be specific. Its boiling point and melting point are characteristics, which are related to the environment of use. And its density is fixed, which is related to the miscibility with other substances.
As for chemical properties, benzenesulfonyl fluoride has high activity. Its sulfonyl group easily reacts with other groups to form new compounds. It can react with hydroxyl groups, amino groups, etc., and is an important agent in organic synthesis. And its fluorine atom gives its specialization, which is changed in the reaction and changes the properties of the product. Such physical and chemical properties make benzenesulfonyl fluoride important in the fields of medicine, agriculture, etc., and are valued by researchers.

Technical Specifications & Labeling

There is Benzenesulfonyl Fluoride today, which is crucial to its technical specifications and identification (product parameters). Its technical specifications need to be clear about the composition, purity geometry, and impurity content, which is related to the quality of the product. The high purity is the best.
Furthermore, in the logo, the name is clear and accurate, and there can be no errors. Product parameters such as characteristics, color, taste and shape need to be clear, and data such as melting boiling point are also indispensable, which is essential for identification. Packaging labels should not be ignored, storage conditions, warnings, etc., should be complete. In this way, this product can be used in applications, safe and effective, and suitable for all things in the chemical industry.

Preparation Method

To make benzenesulfonyl fluoride, the raw materials and process, reaction steps and catalytic mechanism are the key. Take benzenesulfonic acid raw materials, usually its sodium salt or potassium salt, and put them in a reaction kettle together with fluorine-containing reagents. The fluorine-containing reagents used, such as potassium fluoride and sodium fluoride, can also be used.
When reacting, first control the temperature in a moderate range, about one hundred and twenty to one hundred and fifty degrees Celsius. Stirring is constant during this period to make the material mix evenly. The reaction is catalyzed by a base, and potassium carbonate and sodium carbonate can be selected to help the reaction go smoothly.
After the reaction is completed, the products are separated and purified through reduced pressure distillation and extraction. First extract with organic solvent, stratify the organic phase, and then distill under reduced pressure to remove the solvent to obtain pure benzenesulfonyl fluoride. In this way, good products can be obtained for all needs.

Chemical Reactions & Modifications

Benzenesulfonyl fluoride is also a chemical reagent. The reaction and change of benzenesulfonyl fluoride can be investigated. Among the reactions, benzenesulfonyl fluoride often shows specific properties.
When it meets alcohols, it can form an ester, which should be promoted by appropriate catalysis. The change of its bond makes the new chemical produce, and the properties are also changed accordingly. If the temperature is appropriate, it should be smooth and the yield is considerable.
When it encounters amines, it also responds. The nitrogen of amines is combined with the sulfonyl group of benzenesulfonyl fluoride, and the chemical properties are changed. The product is available in the fields of medicine, materials, etc.
However, if you want to improve its reaction and properties, the researcher often adjusts the article. Such as temperature control, agent selection, proportions, in order to achieve the best effect. After many trials and studies, I hope to be able to clarify the law of its application, expand its use, and make benzenesulfonyl fluoride more effective in the process of chemistry.

Synonyms & Product Names

Benzenesulfonyl fluoride is also a stunner in the chemical world. Its synonymous names are numerous and unique. Sold in the market, the titles are also different. Or fluorobenzenesulfonic acid, or fluorine phthalate, all refer to this thing.
This agent is widely used in chemical things. It can be used as an organic synthesis agent to promote the formation of various reactions. Its nature is active, and it can be combined with various things to produce novel qualities.
Although the names are different, its quality is not the same. In the field of chemical industry, researchers know it as benzenesulfonyl fluoride. Therefore, although the names are different, they are actually the same. If used properly, it can add luster to the chemical industry and show the wonderful ability of chemical industry.

Safety & Operational Standards

"Safety and Handling Regulations of Benzenesulfonyl Fluoride"
Benzenesulfonyl fluoride is also a chemical agent. In experimental matters, its safety and handling regulations are of paramount importance.
Where this object is used, the first protection is given. In front of appropriate protective equipment, such as protective clothing, gloves and goggles. These objects can prevent the damage of benzenesulfonyl fluoride to the body, skin and eyes. Its sexual devices irritate, touch the skin, or cause redness, swelling and pain; when it enters the eyes, it is especially harmful to the eyes.
Furthermore, operate in a well-ventilated place. If the volatile gas of benzenesulfonyl fluoride gathers in a narrow chamber, it will be harmful if inhaled. In a well-ventilated place, it can dissipate its gas and reduce damage to the invisible.
When storing, there are also regulations. It should be placed in a cool, dry and ventilated place to avoid fire and heat. This agent may be dangerous in case of heat or open flame.
When using, the amount should be controlled accurately. According to the needs of the experiment, take the amount carefully, not too much or too little. And after use, properly dispose of the remaining agent and utensils. Do not dispose of it at will, when complying with relevant regulations, dispose of it in an environmentally friendly and safe way.
In short, although benzenesulfonyl fluoride is beneficial for chemical research, its safety and operating regulations must not be ignored. Only by following this approach can we ensure the smoothness of the experiment and the well-being of the researchers.

Application Area

Benzenesulfonyl fluoride is widely used in various fields. In the field of biochemistry, it is often a protease inhibitor, which can block the activity of proteases, protect the integrity of egg whites, and make biochemical reactions orderly. In medical research, it is used to make anticoagulants, which are effective in the prevention and treatment of thrombosis. In material science, it involves polymerization, and helps the formation of plastic materials and fibers to increase their firmness and toughness. In organic synthesis, it is a key reagent, promoting the combination of many organic compounds and exploring synthesis paths. In chemical production, it is also an important corner, assisting the production of a variety of fine chemicals and improving product quality. From this perspective, benzenesulfonyl fluoride has the ability to promote the progress of various industries in various fields.

Research & Development

In modern times, chemistry has advanced, and the research of substances has deepened. Benzenesulfonyl Fluoride has gradually become more and more important in various fields of chemistry. I have been studying it for a long time, and at the beginning, I only looked at one or two of its properties, and wanted to understand its use, such as involving maze.
Then relentlessly explored, and gradually gained something. In organic synthesis, it is often a key agent, which can make various reactions go forward and form the desired structure. In biochemical research, it also has an effect, and the properties of the aid protein explain its mechanism.
In the past, many difficulties remain to be solved, such as the control of reactions and the improvement of yield. Today, after repeated experiments, new paths are gradually opening up. Or improve the conditions, or use other agents to increase the yield, the better the effect.
Looking at its development, the prospect is broad. In the future, I hope to shine in the aspects of pharmaceutical creation and material innovation, and contribute to the progress of chemistry to benefit everyone.

Toxicity Research

Those who have studied chemistry in modern times, specializing in the study of poisons, among which Benzenesulfonyl Fluoride, the study of toxicity, is crucial.
Taste its properties, this substance is highly toxic, and entering the body will disrupt the physiological order. During experiments, those who touch it may have discomfort, light skin discomfort, poor breathing, and serious life-threatening.
However, the study of its toxicity is not easy. It is necessary to use a rigorous method, control the amount and test it, and record the reaction in detail. Observe its performance in different environments and doses to get a true solution.
Researchers should be in awe, strictly abide by the procedures, reveal the secrets of its toxicity to the world, and protect everyone from its harm, so as to live up to the responsibility of research.

Future Prospects

The Benzenesulfonyl Fluoride is also a transformative thing. The prospect of its future is now unknown, and there is no place for it. In the field of knowledge, it may be able to assist in the research of new technologies, so as to cure diseases and solve the suffering of life. In the world of materials, it may be new and create special materials, which are generally needed.
And its nature is unique, if it is good to explore, it may be able to open up unknown paths. Before it is discovered, the researcher will reveal its secrets, and use the method of science to make it accessible. Or it can be used to expand the color of many domains, and the extraordinary power of the world's steps, which is what we have been looking forward to.

Where to Buy Benzenesulfonyl Fluoride in China?

As a trusted Benzenesulfonyl Fluoride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading Benzenesulfonyl Fluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of Benzenesulfonyl Fluoride?

Benzenesulfonyl fluoride (Benzenesulfonyl Fluoride) is an organic compound. Its main users cover the following.
In the field of biochemical research, benzenesulfonyl fluoride is often a protease inhibitor. For proteases, it can dissolve the peptide bond of proteins and perform various physiological functions in vivo. Benzenesulfonyl fluoride can covalently bind to the activity check point of proteases, block its catalytic effect, and preserve the integrity of proteins. It is not decomposed by proteases when studying protein structure and function, and protects the purity and stability of protein samples.
Benzenesulfonyl fluoride is also a useful reagent in the process of organic synthesis. It can participate in many reactions, such as reacting with alcohols, amines and other compounds to introduce benzenesulfonyl groups. The introduction of this group can change the physical and chemical properties of compounds, and help chemists obtain new compounds with special properties and functions in the creation of new drugs and the synthesis of special materials.
In pharmaceutical chemistry, benzenesulfonyl fluoride is also widely used. Because it can inhibit specific enzymes, it may be a lead compound. It can be modified and optimized by chemists and is expected to become a drug with therapeutic activity. When developing drugs for specific enzyme-related diseases, benzenesulfonyl fluoride can be used as a starting point for researchers to explore its interaction mode with enzymes and design more effective and specific drug molecules.
In materials science, benzenesulfonyl fluoride can be used to prepare materials with special surface properties. It introduces the hydrophilicity and chemical stability of the surface of the material, which makes the material suitable for different scenarios, such as the preparation of coating materials and film materials, giving the material unique properties.

What are the Physical and Chemical Properties of Benzenesulfonyl Fluoride

Benzenesulfonyl fluoride is also an organic compound. Its physical and chemical properties are quite different, and it is widely used in various fields such as chemistry and medicine.
Looking at its physical properties, benzenesulfonyl fluoride is a colorless to light brown liquid at room temperature, with a pungent smell. Its boiling point is high, about 200. Due to the strong force between molecules, gasification requires more energy. And its density is greater than that of water, so if placed in water, it will sink to the bottom. And its solubility also has characteristics, soluble in many organic solvents, such as ether, chloroform, etc., but its solubility in water is very small, because benzenesulfonyl fluoride is an organic molecule and has hydrophobic properties.
In terms of its chemical properties, benzenesulfonyl fluoride is very active. In its sulfonyl fluoride group, the fluorine atom has strong electronegativity, resulting in a large increase in the polarity of the carbon-fluorine bond. This bond is active and easy to be attacked by nucleophiles. When exposed to water, hydrolysis can gradually occur, and the sulfonyl fluoride group is replaced by a hydroxyl group, while benzenesulfonic acid and hydrogen fluoride are produced. In an alkaline environment, the speed of hydrolysis is particularly slow, because it can neutralize with bases and promote the process of hydrolysis. And benzenesulfonyl fluoride can react with amine compounds to form sulfonamides. This reaction is crucial in organic synthesis and is often the way to prepare sulfonamide drugs or functional materials. And it can react with alcohols under appropriate conditions to form sulfonates. This reaction is also in the field of organic synthesis and is an important means to construct new compounds. In short, the unique physical and chemical properties of benzenesulfonyl fluoride play an important role in the research and industrial production of organic chemistry.

What are the precautions for Benzenesulfonyl Fluoride during use?

Benzenesulfonyl Fluoride (Benzenesulfonyl Fluoride) is a highly toxic chemical, and many things need to be paid special attention when using it.
First, protection must be thorough. When handling this object, you need to wear protective clothing, protective gloves and goggles to prevent it from coming into contact with the skin and eyes. Because it is highly irritating to the skin and eyes, it can cause serious burns if you are not careful. And you need to wear a gas mask, because once the volatile gaseous substances are inhaled, it can cause great damage to the respiratory tract and even endanger life.
Second, the operating environment is very important. It should be in a well-ventilated environment, and it is best to perform relevant operations in a fume hood. In this way, the volatile benzenesulfonyl fluoride can be discharged in time, reducing its concentration in the air and reducing the risk of poisoning. At the same time, the operation site needs to be kept away from fire and heat sources, because benzenesulfonyl fluoride encounters open flames and hot topics, there is a risk of combustion and explosion.
Third, use caution when taking it. Use appropriate tools to measure accurately to avoid spillage. If there is a spill, emergency measures need to be taken immediately. A small amount of spill can be absorbed by inert materials such as sand and vermiculite; if there is a large amount of spill, it needs to build a dike or dig a pit for containment, and contact professionals in time to deal with it.
Fourth, the method of storage should Benzenesulfonyl fluoride should be stored in a cool, dry and well-ventilated place, and should be stored separately from oxidants and alkalis, and should not be mixed. The storage area should also be equipped with suitable materials to contain possible leaks.
Fifth, after use, the utensils used must be thoroughly cleaned to prevent the residual benzenesulfonyl fluoride from affecting subsequent operations. And the waste generated by the experiment should be properly disposed of in accordance with relevant regulations and should not be discarded at will to avoid polluting the environment.

What are the storage conditions for Benzenesulfonyl Fluoride?

Benzenesulfonyl fluoride is a chemical substance, and its storage conditions are crucial. When stored in a cool, dry and well-ventilated place. This is because benzenesulfonyl fluoride is very easy to hydrolyze in contact with water. If it is wet, it will cause it to deteriorate and its efficacy will be greatly reduced. And the temperature also needs to be strictly controlled. If the temperature is too high, it may cause its chemical properties to change, and it may even be dangerous.
Also, it should be placed separately from oxidizing agents and alkalis. The chemical activity of benzenesulfonyl fluoride is not low, and it is co-stored with oxidizing agents, or it may react violently, causing accidents; when it comes into contact with alkalis, it is also easy to cause chemical reactions and damage its quality.
Receptacles should also be carefully selected, and corrosion-resistant materials should be used. Because benzenesulfonyl fluoride is corrosive to a certain extent, containers of ordinary materials may be eroded and cause leakage. And the storage place should be clearly marked to inform everyone of its dangerous characteristics, so that contacts know the need for protection. In this way, benzenesulfonyl fluoride is stable and safe during storage for subsequent use.

What are the synthetic methods of Benzenesulfonyl Fluoride

Benzenesulfonyl fluoride is a commonly used reagent in organic synthesis. The synthesis method is as follows:
First, benzenesulfonate or its salts are used as a halogenating agent. In the past, sodium benzenesulfonate was often mixed with fluorination reagents and reacted under specific conditions. If sodium benzenesulfonate is co-heated with anhydrous hydrogen fluoride, the reaction needs to be carried out in a special corrosion-resistant equipment, because anhydrous hydrogen fluoride is highly corrosive. Potassium fluoride can also be used instead of hydrogen fluoride, and a phase transfer catalyst is added, so that the reaction can occur under milder conditions. Phase transfer catalysts can promote the transfer of ionic reactants from the aqueous phase to the organic phase, thereby accelerating the process of the reaction.
Second, benzene interacts with sulfonyl halogenation reagent and fluorination reagent in sequence. First, benzene and sulfonyl chloride are catalyzed by Lewis acid such as aluminum trichloride to undergo Fu-gram acylation reaction to form benzene sulfonyl chloride. In this reaction, the benzene ring of benzene is electron-rich and is easy to undergo electrophilic substitution reaction with the electrophilic reagent sulfonyl chloride. Then, the obtained benzene sulfonyl chloride is reacted with the fluorination reagent to obtain benzene sulfonyl fluoride. The fluorination reagent is often anhydrous potassium fluoride, etc., and is heated and refluxed in a suitable solvent to complete this conversion.
Third, aryl boronic acid derivatives are used as starting materials. First, the aryl boric acid is reacted with the sulfonyl halogenation reagent to form the aryl sulfonyl halogen intermediate, and then the benzene sulfonyl fluoride is obtained through the fluorination step. The advantage of this route is that the aryl boric acid derivative is easier to prepare, and the reaction selectivity is quite high, which can effectively avoid the occurrence of some side reactions.
In short, there are many methods for synthesizing benzene sulfonyl fluoride, each with its own advantages and disadvantages. Experimenters should choose carefully according to specific needs, availability of raw materials and reaction conditions.