What are the main uses of 4-aminotrifluorotoluene (Aminobenzotrifluoride, 4-)?

4-Aminotrifluorotoluene has a wide range of uses. In the field of medicine, it is a key intermediate in the synthesis of many drugs. For example, when synthesizing some antidepressants, 4-Aminotrifluorotoluene can undergo a series of chemical reactions to build a drug activity structure, which can help the drug achieve specific targets in the nervous system and relieve depression symptoms. In the field of pesticides, it is often used as a raw material for the synthesis of high-efficiency and low-toxicity pesticides. With its unique chemical structure, it can give pesticides good insecticidal, bactericidal or herbicidal activity, and is relatively friendly to the environment and reduces the negative impact on the ecology. In the dye industry, it can participate in the synthesis of dyes with excellent performance. The dyes made from it are brightly colored and have good fastness, and are widely used in textile printing and dyeing and other industries to make fabrics show a gorgeous and It is also used in organic synthesis research to provide important starting materials for researchers to build complex organic molecular structures, assist in the development of new functional materials, explore new chemical reaction paths, and promote the development of organic chemistry.

What are the physical properties of 4-aminotrifluorotoluene (Aminobenzotrifluoride, 4-)

4-Aminotrifluorotoluene (4-Aminobenzotrifluoride) is also an organic compound. Its specific physical properties are described below.

Looking at its properties, 4-aminotrifluorotoluene is a colorless to light yellow liquid at room temperature and pressure, clear and transparent, with no impurities visible to the naked eye. If placed in a place with sufficient light or in contact with air for a long time, its color may become slightly darker, but the essence remains unchanged.

As for the smell, this compound emits a special aromatic smell, although not pungent, it is also quite unique, and is easily recognized in chemical laboratories or industrial sites.

When it comes to melting point, 4-aminotrifluorotoluene has a low melting point, about -25 ° C. This property makes it liquid at room temperature, which is convenient for the operation and application of various chemical reactions. If the temperature drops below the melting point, it will gradually solidify into a solid state, and the form will change from a flowing liquid to a solid solid.

For boiling point, the boiling point of 4-aminotrifluorotoluene is about 200-203 ° C. When heated to the boiling point, the compound will change from a liquid state to a gaseous state, and vaporization will occur. The value of this boiling point is of great significance in chemical operations such as distillation and separation, and is a key parameter for accurately controlling reaction conditions.

In terms of solubility, 4-aminotrifluorotoluene is insoluble in water. Due to the characteristics of its molecular structure, the interaction between water molecules is weak. However, it is soluble in a variety of organic solvents, such as ethanol, ether, acetone, etc. In organic solvents, 4-aminotrifluorotoluene can be uniformly dispersed to form a uniform and stable solution. This property makes it widely used in the field of organic synthesis, often as a reaction solvent or reactant carrier.

In terms of density, the density of 4-aminotrifluorotoluene is slightly higher than that of water, about 1.29 g/cm ³. This density difference can be achieved by means of layering principle according to different densities when operations such as liquid-liquid separation are involved.

In addition, the vapor pressure of 4-aminotrifluorotoluene cannot be ignored. At a specific temperature, its vapor pressure reflects the tendency of the compound to evaporate from liquid to gaseous state. The vapor pressure increases with increasing temperature, which means that in high temperature environments, 4-aminotrifluorotoluene is more volatile into gases. During storage and use, it is necessary to pay attention to the latent risks caused by changes in vapor pressure, such as gas leakage.

What are the chemical properties of 4-aminotrifluorotoluene (Aminobenzotrifluoride, 4-)

4-Aminotrifluorotoluene is one of organic compounds. It has many chemical properties.

In this compound, the amino group and trifluoromethyl group are attached to the benzene ring. The amino group is an active group with a certain alkalinity, which can react with acids to form corresponding salts. Because nitrogen atoms have lone pair electrons, it can participate in nucleophilic substitution reactions. Under suitable conditions, it can react with electrophilic reagents such as halogenated hydrocarbons to form new carbon-nitrogen bonds.

And trifluoromethyl is a strong electron-absorbing group, which has a significant impact on the electron cloud density of the benzene ring and reduces the electron cloud density of the benzene ring. This effect results in a decrease in the electrophilic substitution activity of the benzene ring and a change in the reaction check point. Usually, the electrophilic substitution reaction is more likely to occur in the adjacent and para-position of the amino group, but due to the electron-absorbing effect of trifluoromethyl, the proportion of meta-substitution products will also increase.

In addition, 4-amino trifluorotoluene also has specific properties in redox reactions. Amino groups can be oxidized to form oxidation products such as nitro groups; while under the action of appropriate reducing agents, benzene rings can undergo hydrogenation and reduction reactions, but specific catalysts and reaction conditions are required.

Its chemical properties make it widely used in the field of organic synthesis and can be used as a key intermediate for the preparation of fine chemicals such as medicines, pesticides, and dyes. For example, in pharmaceutical synthesis, by structurally modifying it, drug molecules with specific biological activities can be developed.

What are the production methods of 4-aminotrifluorotoluene (Aminobenzotrifluoride, 4-)

There are several common methods for preparing 4-aminotrifluorotoluene (4-Aminobenzotrifluoride).

One is prepared by reduction reaction using p-nitrotrifluorotoluene as the starting material. This reduction reaction often uses iron powder and hydrochloric acid as the reducing agent. At an appropriate temperature and reaction time, the nitro group of p-nitrotrifluorotoluene can be reduced to an amino group to obtain 4-aminotrifluorotoluene. The reaction mechanism is based on the production of new hydrogen in hydrochloric acid solution from iron powder. The new hydrogen has strong reductive properties and can gradually reduce the nitro group to an amino group.

The other is prepared by diazotization and Sandmeyer reaction with m-trifluoromethylaniline as the raw material. First, m-trifluoromethylaniline is reacted with sodium nitrite under acidic conditions to form diazonium salts. Then, in the presence of cuprous chloride and other catalysts, the diazonium salt undergoes a Sandmeier reaction, the diazonium group is replaced by chlorine atoms, and then ammonia replaces the chlorine atom through an aminolysis reaction, and finally 4-aminotrifluorotoluene is obtained. In this process, the diazotization reaction needs to strictly control the temperature and reaction conditions to prevent the decomposition of diazonium salts.

Third, trifluoromethylbenzene can be used as the starting material, and the nitration reaction is first carried out to introduce nitro groups into the benzene ring to obtain p-nitrotrifluorotoluene, and then the reduction reaction is carried out as the first method to obtain the target product. The nitrification reaction usually uses mixed acid (a mixture of nitric acid and sulfuric acid) as the nitrification reagent. According to the positioning rules of the benzene ring, the nitro group mainly enters the para-position of the trifluoromethyl group. The subsequent reduction steps are as described above.

The above methods have their own advantages and disadvantages. In actual production, the most suitable method should be selected to prepare 4-amino trifluorotoluene according to the availability of raw materials, cost, and difficulty in controlling reaction conditions.

What is the price range of 4-Aminotrifluorotoluene (Aminobenzotrifluoride, 4-) in the market?

4-Aminotrifluorotoluene (4-Aminobenzotrifluoride), the price of this product in the market, it is difficult to determine its range. The change in its price depends on many reasons.

One is related to the preparation method. If it is made by a convenient and efficient method, the yield is high and the cost is low, and the price may be slightly cheaper. However, if the preparation process is complicated, multiple steps are required, and the yield of each step is limited, and many expensive reagents and catalysts are required, the cost will rise, and the price will be high.

Second, the price of raw materials is also the main reason. If the price of raw materials fluctuates frequently, or the raw materials are rare, such as specific halides and fluorine-containing raw materials required for the preparation of 4-aminotrifluorotoluene, if the price rises, the price of 4-aminotrifluorotoluene will also rise.

Third, the market supply and demand shape its price. If the market demand for 4-aminotrifluorotoluene is strong, but the supply is insufficient, such as in the fields of pharmaceutical synthesis, pesticide research and development, and materials science, there is a lot of demand, and the supply of producers is limited, the price will rise. On the contrary, if the supply exceeds the demand, the producer will sell the goods, and the price may drop.

Fourth, the impact of the current situation should not be underestimated. If the government regulates, if the environmental protection regulations are stricter and the manufacturer complies with the regulations, the cost will increase and the price will also rise. If trade policies change, tax increases or decreases, the price can change.

In summary, the price of 4-aminotrifluorotoluene fluctuates between hundreds of yuan and thousands of yuan per kilogram due to preparation, raw materials, supply and demand, etc., it is difficult to determine the exact value.