What is the chemical structure of 6-Chloro-1H-Purine-2-Sulfonyl Fluoride?
6-Chloro-1H-purine-2-sulfonyl fluoride, this is an organic compound. Looking at its name, it can be inferred that its structure is based on a purine ring. The purine ring is a heterocyclic structure containing nitrogen, with the shape of a double ring. One is a six-membered pyridine ring and the other is a five-membered imidazole ring. The two are fused together.
At the 6th position of the purine ring, there is a chlorine atom, which is covalently bonded to the carbon atom of the purine ring. At the 2nd position, there is a sulfonyl fluoride group. In the sulfonyl fluoride group, the sulfur atom is connected with two oxygen atoms by a double bond, and is combined with the monofluorine atom and the carbon atom at the second position of the purine ring.
In this compound, the nitrogen atom in the purine ring imparts its basic properties, and the chlorine atom can affect the polarity and chemical reactivity of the molecule due to its electronegativity and atomic radius. In the sulfonyl fluoride group, the fluorine atom is active and easily participates in reactions such as nucleophilic substitution, while the sulfonyl group can make the molecule have certain hydrophilicity and chemical stability. Such a structure creates the unique physical and chemical properties of the compound, which may have important uses in the fields of organic synthesis and medicinal chemistry.
What are the main uses of 6-Chloro-1H-Purine-2-Sulfonyl Fluoride?
6-Chloro-1H-purine-2-sulfonyl fluoride has a wide range of uses. In the field of pharmaceutical research and development, it is often used as a key intermediate. Because the purine structure is common in many biologically active molecules, by introducing 6-chloro-1H-purine-2-sulfonyl fluoride, compounds with specific pharmacological activities can be constructed to help create new drugs, or used to improve the efficacy of existing drugs and reduce side effects.
In the field of organic synthesis, it can act as a sulfonylation agent. Sulfonyl fluoride groups are highly reactive and can react with many nucleophilic reagents, such as alcohols, amines, etc., thereby introducing sulfonyl functional groups, enriching the structure and properties of organic molecules, and synthesizing various functional materials or intermediates with special reactivity.
In the field of materials science, or can participate in the preparation of special materials. After polymerization with specific monomers, the material is endowed with unique chemical and physical properties, such as improved material stability, hydrophilicity, and even some special response properties to meet the specific requirements of material properties in different application scenarios.
In addition, in chemical biology research, it may be used to label specific biomolecules. Using the reactivity of sulfonyl fluoride with nucleophilic check points in biomolecules, it can achieve the labeling of biological macromolecules such as proteins and nucleic acids, and help explore the function, positioning and interaction mechanism of biomolecules, providing a powerful tool for life science research.
What are the physical properties of 6-Chloro-1H-Purine-2-Sulfonyl Fluoride?
6-Chloro-1H-purine-2-sulfonyl fluoride, this is a unique chemical substance. Its physical properties are worth exploring.
Under normal temperature and pressure, or in the form of white to white solid powder. This form is conducive to storage and transportation, and in many chemical reactions, due to its large specific surface area, it can show good reactivity.
When it comes to melting point, this substance has a specific melting point value, but the exact value needs to be determined by precise experiments. The existence of the melting point indicates that it needs to absorb a specific amount of heat when transitioning from solid to liquid. This property is crucial in the purification and identification of substances, and can be used as an important basis for judging the purity of the substance.
As for solubility, 6-chloro-1H-purine-2-sulfonyl fluoride exhibits a certain solubility in organic solvents. In some polar organic solvents, such as dichloromethane, N, N-dimethylformamide, it may show a good solubility. In water, its solubility may be relatively limited. This difference in solubility makes it possible to carefully select suitable solvents according to the needs of the reaction during the chemical reaction to promote the smooth progress of the reaction.
Furthermore, its density is also a key physical property. Although the specific density data needs to be accurately measured, its density characteristics affect the distribution of the substance in solution. In some reaction processes involving phase separation, extraction, etc., density considerations are essential.
The physical properties of 6-chloro-1H-purine-2-sulfonyl fluoride are interrelated and jointly affect their application in the chemical field. From the setting of reaction conditions to the separation and purification of products, they are all closely related to these physical properties, so it is essential to study them in depth.
What are the synthesis methods of 6-Chloro-1H-Purine-2-Sulfonyl Fluoride?
The synthesis of 6-chloro-1H-purine-2-sulfonyl fluoride is a crucial topic in the field of chemistry. In the past, to synthesize this compound, several paths were often followed.
One, it can be started by purine compounds. First, the purine matrix is modified with specific substituents, and the appropriate halogenating reagents, such as chlorine-containing reagents, introduce chlorine atoms at the 6 position of the purine ring to form 6-chloropurine derivatives. This process requires careful selection of reaction conditions, such as reaction temperature, solvent and catalyst, to ensure the precise introduction of chlorine atoms and avoid side reactions at other positions.
Then, the sulfonylation modification is carried out for the 2-position of the purine ring. Sulfonylation reagents are often used to connect the sulfonyl group to the 2-position under suitable bases and reaction environments. In this step, the strength, reaction time and temperature of the base are very important to control. There is a slight difference in the pool, or the reaction yield is reduced or by-products are formed. Finally, the sulfonyl group is converted into sulfonyl fluoride by fluorination reagents. In this step, the reaction parameters need to be carefully adjusted to obtain the target product 6-chloro-1H-purine-2-sulfonyl fluoride.
Second, or from simple compounds containing sulfonyl fluoride and chlorine, purine rings can be constructed by cyclization reaction. This approach requires the design of delicate reaction strategies, so that each functional group can react in an orderly manner under specific conditions, and gradually piece together the purine structure. In the meantime, it is necessary to pay attention to the stability and reactivity of the reaction intermediates, and adjust the reaction process in a timely manner to achieve the purpose of efficient synthesis.
No matter what method, careful study and precise regulation of each step of the reaction are required to effectively synthesize 6-chloro-1H-purine-2-sulfonyl fluoride, providing key raw materials for research and application in related fields.
What are the precautions for 6-Chloro-1H-Purine-2-Sulfonyl Fluoride during use?
6-Chloro-1H-purine-2-sulfonyl fluoride, when using, many things need to be paid attention to.
First, it is chemically active and has special properties. When touching, do not be negligent. Wear comprehensive protective equipment, such as gloves, goggles, protective clothing, etc., to prevent it from coming into contact with the skin and eyes. If you accidentally touch it, rinse it with plenty of water immediately and seek medical attention as appropriate.
Furthermore, in terms of operating environment, be sure to have good ventilation. Because it may volatilize some harmful substances, good ventilation can allow harmful gases to disperse in time, so as not to accumulate, so as to ensure the safety of operators. When operating, it should also be kept away from fire and heat sources. Because of its flammability or heat instability, if there is a slight carelessness, there is a risk of fire or explosion.
In addition, storage should be placed in a dry, cool place, and properly sealed. Avoid it from moisture and heat, causing deterioration, affecting its chemical properties and use efficiency. Storage should also be kept away from other chemicals, especially those that may react with it, to prevent interaction and cause danger.
When using this substance, be sure to handle it accurately. When weighing and taking, act according to the standard process. The utensils used must also be clean, dry and accurate. If taken improperly, it may cause deviations in experimental results or cause accidents.
Furthermore, after use, the remaining materials should not be discarded at will. It needs to be properly disposed of in accordance with relevant regulations to prevent pollution to the environment and harm the ecology.
In short, when using 6-chloro-1H-purine-2-sulfonyl fluoride, every step needs to be careful, follow the procedures, and do not slack off to ensure safety and achieve the intended purpose.