4 Bromobenzotrifluoride
Fluoride

4-Bromobenzotrifluoride

Duxiu Chemical

Specifications

HS Code

780655

Chemical Formula C7H4BrF3
Molecular Weight 225.009
Appearance Colorless to light yellow liquid
Boiling Point 194 - 196 °C
Melting Point -30 °C
Density 1.582 g/mL at 25 °C
Vapor Pressure 0.44 mmHg at 25 °C
Flash Point 76 °C
Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
Refractive Index 1.4775

As an accredited 4-Bromobenzotrifluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500 - gram bottle of 4 - Bromobenzotrifluoride, tightly sealed for safe storage.
Storage 4 - Bromobenzotrifluoride should be stored in a cool, well - ventilated area away from heat sources, open flames, and oxidizing agents. Keep it in a tightly sealed container to prevent leakage. Store it in a dedicated chemical storage cabinet, segregated from incompatible substances. This helps maintain its stability and reduces the risk of chemical reactions and safety hazards.
Shipping 4 - Bromobenzotrifluoride is shipped in tightly - sealed, corrosion - resistant containers. It's transported by specialized chemical carriers following strict safety protocols to prevent spills and ensure safe delivery due to its potentially hazardous nature.
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4-Bromobenzotrifluoride
General Information
Historical Development
4 - Bromobenzotrifluoride, organic compounds are also. Its research and development process is quite impressive. In the past, chemists devoted themselves to exploring the synthesis of fluorinated aromatic compounds. At first, the technology was not refined, and the synthesis of this compound was quite difficult. However, the researchers were unyielding and went through countless attempts and improvements.
In the early years, only a small amount of products could be obtained by complicated and inefficient methods. With the passage of time, the chemical theory has been improved day by day, and the experimental technology has also made breakthroughs. The discovery of new catalysts and the optimization of reaction conditions have greatly improved the synthesis efficiency of 4-Bromobenzotrifluoride. From the initial difficult search to the relatively convenient preparation of large quantities today, the development of this compound is a testament to the continuous progress of chemical research and has laid a solid foundation for the subsequent expansion of related fields.
Product Overview
4 - Bromobenzotrifluoride, organic compounds are also. Its shape is colorless to light yellow liquid, with a special odor. The melting point of this substance is quite low, and the boiling point is within a certain range. Its chemical properties are active and it is widely used in the field of organic synthesis.
can be used as intermediates in the synthesis of medicines, pesticides and dyes. Its structure contains bromine atoms and trifluoromethyl, giving it unique reactivity. Through specific chemical reactions, bromine atoms can be replaced and other functional groups can be introduced to construct complex organic molecular structures.
The presence of trifluoromethyl enhances molecular fat solubility and stability. In the pharmaceutical industry, it helps drug molecules to penetrate biofilms and improve drug efficacy. And because of its chemical properties, it exhibits good selectivity and controllability in the synthesis reaction, which is favored by organic synthesis chemists and occupies an important position in the field of modern organic synthesis chemistry.
Physical & Chemical Properties
4 - Bromobenzotrifluoride is an organic compound, and its physical and chemical properties are particularly important. Looking at its physical properties, it is a colorless to light yellow liquid at room temperature, with a special odor. Its boiling point is about 189 - 191 ° C. At this temperature, the substance changes from liquid to gaseous state, showing its volatile characteristics. The melting point is -27 ° C. Below this temperature, it solidifies as a solid state. The density is about 1.57 g/cm ³, which is heavier than water and will sink in water.
In terms of its chemical properties, it is active because it contains bromine atoms and trifluoromethyl. Bromine atoms can undergo substitution reactions and can be replaced by other atoms or groups under appropriate conditions. Trifluoromethyl has strong electron absorption, which affects the distribution of molecular electron clouds, reduces the density of benzene ring electron clouds, and changes its electrophilic substitution reactivity. This compound has a wide range of uses in the field of organic synthesis. Due to its physical and chemical properties, it can participate in many chemical reactions and provide key raw materials for the synthesis of complex organic molecules.
Technical Specifications & Labeling
Nowadays, there are chemical substances, named 4-Bromobenzotrifluoride. Its process specifications and identification (commodity parameters) are of paramount importance. In terms of its process specifications, it is necessary to precisely control the synthesis method, the ratio of raw materials, the reaction temperature and the time and length must be accurate, so that the reaction is sufficient and impurities are less. And the separation and purification techniques cannot be ignored to achieve high purity requirements. As for the identification, its chemical characteristics, hazard warnings and other commodity parameters should be detailed. On the packaging, clearly mark the name, chemical formula, content, hazard identification, etc., so that the user can see at a glance, its nature and use of attention, so that it can be used safely and accurately, in order to comply with the process specifications and identification (commodity parameters) criteria.
Preparation Method
In order to make 4 - Bromobenzotrifluoride, the raw materials and production process are the key. P - bromotoluene can be selected as the initial raw material and formed through specific reaction steps.
In the first step, p - bromotoluene and bromine under the action of light or initiator, the radical substitution reaction is carried out, so that the hydrogen on the methyl is replaced by bromine to obtain bromomethyl p - bromobenzene. In this step, the reaction temperature and time need to be controlled to maintain the yield and purity.
In the second step, bromomethyl p - bromobenzene and anhydrous hydrogen fluoride are combined in an autoclave. Under the action of suitable catalysts such as antimony pentachloride, the nucleophilic substitution reaction is carried out, and the bromine is replaced by fluorine, so 4 -
In this process, the control of the reaction conditions is very important. Temperature, pressure, and catalyst dosage are all related to the reaction process and product quality. In addition, the corrosion resistance of the equipment also needs to be considered, because it involves corrosive substances such as hydrogen fluoride. In this way, following this process, an ideal 4-Bromobenzotrifluoride product may be obtained.
Chemical Reactions & Modifications

In the past research, the reverse method was followed many times, but the effect was not ideal. Or because of the harshness of the reverse parts, or the poor catalysis, the yield was not good, and the side effects were not good.
In the near future, we are working on the new theory, and we will explore it with improved methods. To integrate the efficiency and efficiency of the reverse, it is easier to catalyze, and we hope to obtain better results. In general, it is found that with a certain degree of efficiency and efficiency, and with the help of new catalysis, the rate of reaction has increased, and the efficiency has also increased significantly, and the side effects have increased significantly.
Therefore, the modification of the reverse is not possible overnight, and it is necessary to rely on the reason and diligently work hard to obtain the best method to promote the transformation of the 4-Bromobenzotrifluoride.
Synonyms & Product Names
4 - Bromobenzotrifluoride, this substance is also called p-bromotrifluorotoluene. There are many other names, all of which refer to the same substance. Looking at the field of chemical industry, the same substance has different names due to different uses, production methods, and origins. This 4 - Bromobenzotrifluoride is very important in the process of organic synthesis. Or use it as raw material to make dyes, medicines, and pesticides. Its different names, although the names are different, the substances referred to are not special. In the field of chemistry, the accurate identification of the same and different names is the basis of scientific research and production. If confused with its name, it will cause disorder in operation and hinder progress. Therefore, chemical researchers and practitioners should know the different names of the same substance in detail, and the same should be true in 4-Bromobenzotrifluoride, and must not be neglected.
Safety & Operational Standards
4 - Bromobenzotrifluoride safety and operating practices
4 - Bromobenzotrifluoride, chemical substances are also. When using and operating, it is necessary to strictly abide by safety and operating practices to avoid all dangers.
#Storage rules
This substance should be stored in a cool, dry and well-ventilated place. Keep away from fires, heat sources, and must not be stored with oxidants, alkalis, etc. The cover is dangerous because of its active chemical properties, mixing with other substances, or causing chemical reactions. The storage area should be equipped with suitable materials to contain leaks.
#Operation essentials
When operating, the operator should be professionally trained and familiar with the operation procedures. Appropriate protective equipment must be worn, such as protective glasses, protective gloves, protective clothing, etc., to prevent substances from coming into contact with the skin and eyes. The operation site must be well ventilated to avoid gas accumulation. When using the substance, the action should be slow and handle it with care to prevent the container from being damaged and causing it to leak.
#Response to leakage
If a leak unfortunately occurs, the first thing to do is to quickly evacuate the personnel from the leaked contaminated area to a safe area, isolate them, and strictly restrict access. Emergency responders must wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Do not let the leakage come into contact with combustible substances. In the event of a small amount of leakage, it can be mixed with sand, dry lime or soda ash and collected in an airtight container. Large leaks should be built embankment or dig a pit to contain, and transferred to a tanker or special collector by pump, recycled or transported to a waste disposal site for disposal.
#First Aid
If you accidentally come into contact with the skin, you should immediately remove the contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical attention. If splashing into the eyes, you should immediately lift the eyelids, rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes, and seek medical attention immediately. If inhaling, quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties, give oxygen; if breathing stops, immediately perform artificial respiration and send to the hospital.
All operations involving 4-Bromobenzotrifluoride should take safety as the priority and strictly abide by the operating specifications, so as to ensure the safety of personnel and avoid accidents.
Application Area
4 - Bromobenzotrifluoride, the application field of this substance is quite extensive. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize many specific drugs, which is of great significance for the treatment of diseases. In the field of materials science, it can improve the properties of materials through specific reactions, such as enhancing their stability and corrosion resistance. In the field of organic synthesis, it is an indispensable raw material. Through various reaction paths, complex organic molecular structures can be constructed.
Looking back at the past, many scholars have dedicated themselves to exploring its potential in different fields. Today, with the advance of science and technology, its application may be more expanded. In the future, emerging technologies, such as high-end electronic materials, cutting-edge pharmaceutical research and development, may emerge, injecting new energy into the development of related industries and driving them towards new frontiers.
Research & Development
We are committed to the research of 4 - Bromobenzotrifluoride. This compound has unique properties and great potential in the field of organic synthesis.
At the beginning, we explored its synthesis path, which has been subject to many twists and turns. The traditional method is either expensive or the yield is low. We then dedicated ourselves to studying, trying new reaction conditions and improving catalysts.
After months of work, we finally obtained a method that can efficiently synthesize 4 - Bromobenzotrifluoride. The yield is greatly improved compared with the past, and the cost is controllable.
Then, explore its application. It is found that it can be used in the synthesis of pharmaceutical intermediates, which can lay the foundation for the development of new drugs; in the field of materials science, it is expected to improve material properties.
Looking to the future, the research and development prospects of 4-Bromobenzotrifluoride are broad. We should make unremitting efforts to explore more potential values to promote the progress of the chemical field.
Toxicity Research
The toxicity of 4 - Bromobenzotrifluoride is studied. This compound has a colorless liquid appearance and a special odor. It is widely used in the chemical industry, but toxicity research is indispensable.
After experiments, 4 - Bromobenzotrifluoride does have an effect on organisms. It may enter the body through the respiratory tract, skin and other routes. In animal experiments, it can cause respiratory discomfort, or even damage organs such as liver and kidney. And long-term exposure, or potential carcinogenic risk.
To observe the mechanism of its toxic action, it may be related to interfering with the normal metabolism of cells. Specific groups in its molecular structure, or interact with biomacromolecules, disrupt cell physiological functions.
However, the research on the toxicity of 4-Bromobenzotrifluoride is still in development. Many details are still unknown, and it is necessary to expand the method and explore it in depth to clarify the full picture of its toxicity and provide evidence for safe production, rational application and the formulation of protective measures.
Future Prospects
Prospects of the future, in 4 - Bromobenzotrifluoride this thing, there is a lot of potential. In today's world, science and technology are new, and the technology is new, and the use of this compound in the field must be cured.
Its chemical properties, and it is special, can be the foundation of new research, so that diseases can be solved and people can be healthy. It is also a family of materials, or it can help new materials to be born, durable and durable, and useful.
There may be a new way forward, but we who study it must use scientific methods to explore its secrets and promote its development. During the month of August, it will be used to thrive in work and improve people's livelihood, and it will be a bright pearl that has not yet been completed.
Where to Buy 4-Bromobenzotrifluoride in China?
As a trusted 4-Bromobenzotrifluoride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Bromobenzotrifluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Bromobenzotrifluoride?
4-Bromobenzotrifluoride, that is, 4-bromotrifluorotoluene, has a wide range of main uses.
In the field of organic synthesis, this is a very critical intermediate. Due to its unique molecular structure, it contains bromine atoms and trifluoromethyl, giving it special reactivity. With the activity of bromine atoms, it can combine with various nucleophiles through many classic organic reactions, such as nucleophilic substitution reactions, to form novel carbon-carbon bonds, carbon-heteroatom bonds, etc. For example, it can react with nucleophiles such as alcohols and amines to generate corresponding substitution products, which is of great significance in the fields of drug synthesis and pesticide creation.
In the field of drug development, 4-bromotrifluorotoluene plays an indispensable role. Many biologically active drug molecules need to be introduced with trifluoromethyl to improve the lipophilicity, metabolic stability and bioavailability of the drug. As an important starting material, 4-bromotrifluorotoluene can be constructed with specific pharmacological activities through a series of chemical transformations.
In the field of materials science, it is also useful. Due to the strong electron absorption and unique physicochemical properties of trifluoromethyl, materials synthesized from 4-bromotrifluorotoluene often have excellent properties. For example, in the synthesis of polymer materials, the introduction of trifluoromethyl-containing structural units can improve the heat resistance, chemical corrosion resistance and surface properties of materials, and is suitable for the preparation of high-performance engineering plastics, coatings and other materials.
In addition, in the production of fine chemicals, 4-bromotrifluorotoluene is also an important raw material for the preparation of special functional compounds. It can participate in the synthesis of special dyes, fragrances and other fine chemicals, giving these products unique properties and application value.
In summary, 4-bromotrifluorotoluene has key uses in many fields such as organic synthesis, drug development, materials science and fine chemical production, and occupies an important position in modern chemical industry and scientific research.
What are the physical properties of 4-Bromobenzotrifluoride?
4-Bromotrifluorotoluene is also an organic compound. It has unique physical properties, let me explain it to you in detail.
First of all, under room temperature and pressure, 4-bromotrifluorotoluene is a colorless to light yellow transparent liquid, which is clear in appearance, just like autumn dew. Its smell is specific and slightly irritating, and you can feel a special smell when you smell it.
When it comes to the boiling point, it is about 189-191 ° C. When the temperature reaches this point, this substance gradually converts from a liquid state to a gaseous state, such as a cloud rising. The characteristics of the boiling point are crucial in chemical operations such as separation and purification, and other substances can be used accordingly.
Melting point is about -27 ° C. When the temperature drops to this temperature, the liquid 4-bromotrifluorotoluene will condense into a solid state, just like water turns into ice when it meets cold. This melting point is also one of its inherent physical properties. In storage, transportation and other links, it is necessary to pay attention to the effect of temperature on its physical state.
Furthermore, its density is about 1.704 g/mL (25 ° C). In comparison with water, the density of water is 1 g/mL, which shows that the density of 4-bromotrifluorotoluene is greater than that of water. If the two are mixed, 4-bromotrifluorotoluene will sink underwater, like a stone falling into the abyss.
In terms of solubility, 4-bromotrifluorotoluene is insoluble in water, like oil and water, and is incompatible with each other. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc., just like fish entering a river, it can be mixed with organic solvents. This solubility property is widely used in organic synthesis, extraction and other fields.
The vapor pressure of 4-bromotrifluorotoluene also has its value. At a specific temperature, the pressure when its vapor reaches equilibrium with the liquid state in a closed container reflects the degree of its volatilization. This property is closely related to the safety of the storage and use environment. If the vapor pressure is too high, it is very easy to evaporate. It is necessary to pay attention to fire prevention and explosion prevention and other matters.
In summary, the physical properties of 4-bromotrifluorotoluene are diverse and are of great significance in many fields such as chemical industry and scientific research. We should carefully investigate and make good use of its properties to achieve twice the result with half the effort.
What is the chemistry of 4-Bromobenzotrifluoride?
4-Bromotrifluorotoluene, which is a colorless to light yellow liquid with a special odor. The chemical properties of this substance are quite critical and are related to many applications.
From the perspective of reactivity, the bromine atom activity on the aromatic ring is prominent. Due to the strong electron-absorbing effect of trifluoromethyl, the adjacent and para-electron cloud density of bromine atoms decreases, making it vulnerable to nucleophilic attack, triggering nucleophilic substitution reactions. For example, under suitable conditions with sodium alcohol, bromine can be replaced by alkoxy groups to obtain corresponding ether compounds. This reaction is an important path for the organic synthesis of trifluoromethyl ethers.
Furthermore, its participation in metal catalytic coupling reactions is also of great significance. Under the catalysis of palladium, it can occur Suzuki coupling reaction with boric acid compounds to form new carbon-carbon bonds. This is a common method for synthesizing complex aromatic hydrocarbons containing trifluoromethyl, and is widely used in the fields of medicinal chemistry and materials science.
And trifluoromethyl itself has unique properties. Its strong electronegativity and small steric resistance make 4-bromotrifluorotoluene have high chemical stability and thermal stability. At the same time, trifluoromethyl affects molecular polarity and fat solubility. In drug development, the introduction of this group can often change the pharmacokinetic properties and biological activities.
In addition, 4-bromotrifluorotoluene has good stability to some chemical reagents. Under normal conditions, it has a certain tolerance to common acids and bases, but hydrolysis or other degradation reactions may occur when strong acids and bases are acted on at high temperatures for a long time.
In short, 4-bromotrifluorotoluene is rich in chemical properties and plays an important role in organic synthesis, drug development, material preparation and other fields. It provides a key structural unit for the creation of novel functional materials and high-efficiency drugs.
What are the preparation methods of 4-Bromobenzotrifluoride?
4-Bromotrifluorotoluene, there are several common methods for preparation as follows.
First, p-bromotoluene is used as a starting material and is prepared by trifluoromethylation. In this reaction, cuprous bromide is used as a catalyst, and trifluoromethylation reagents, such as zinc trifluoromethylhalide, are reacted in a specific organic solvent, such as N, N-dimethylformamide, at an appropriate temperature. The methyl group of p-bromotoluene is substituted with the trifluoromethylation reagent under the action of the catalyst to generate 4-bromotrifluorotoluene. Its advantage is that the raw material is relatively easy to obtain and the reaction conditions are still operable. However, it is necessary to pay attention to the amount of catalyst and the control of the reaction temperature to avoid side reactions.
Second, trifluorotoluene is used as the starting material and prepared by bromination reaction. In this process, trifluorotoluene is used as the substrate, and in the presence of an initiator such as benzoyl peroxide, it undergoes a free radical substitution reaction with bromine. Usually carried out under light or heating conditions, bromine atoms replace hydrogen atoms on the benzene ring to generate 4-bromotrifluorotoluene. This method is relatively simple to operate and the yield is acceptable. However, attention should be paid to the corrosiveness and toxicity of bromine during the reaction process, as well as the effect of reaction conditions on the selectivity of the product.
Third, it is prepared from 4-amino trifluorotoluene by diazotization and bromination. First, 4-amino trifluorotoluene and sodium nitrite undergo diazotization under acidic conditions to form diazonium salts, and then the diazonium salt interacts with reagents such as cuprous bromide to undergo Sandmeier reaction, and the diazonium group is replaced by bromine atoms to obtain 4-bromotrifluorotoluene. This method is more complicated, but it may provide an effective way for the preparation of specific needs. The diazotization reaction conditions need to be strictly controlled during operation to ensure the safety of the reaction and the purity of the product.
What 4-Bromobenzotrifluoride need to pay attention to when storing and transporting
4-Bromotrifluorotoluene is also an organic compound. During storage and transportation, all matters must be carefully paid attention to.
When storing, the first environment. It should be placed in a cool and ventilated warehouse. This compound is prone to change when heated, and the high temperature environment may be dangerous, so the stability can be guaranteed in a cool place. Ventilation is also critical to prevent the accumulation of harmful gases and reduce the risk of explosion and poisoning.
Times and packaging. It is necessary to ensure that the packaging is complete and sealed. Because it is volatile and corrosive to a certain extent, if the packaging is damaged, it is easy to leak, damage the environment and personal safety. Packaging materials must also be considered, and those that are resistant to corrosion and can be effectively isolated should be selected.
Furthermore, when storing, it should be stored separately from oxidants and alkalis. This compound is chemically active, mixed with oxidants, or has a violent oxidation reaction; when it encounters alkalis, it may also cause chemical reactions, causing fires, explosions and other accidents.
As for transportation, transportation vehicles must meet safety standards. Corresponding fire equipment and leakage emergency treatment equipment should be prepared in the car to prevent emergencies on the way. The transportation process should be smooth, avoid bumps and vibrations, and prevent packaging damage.
And transportation personnel also need professional training, familiar with the characteristics of this compound and emergency treatment methods. When loading and unloading, it must be handled lightly, and it is strictly forbidden to drop and heavy pressure to ensure the safety of the goods.
Therefore, when storing and transporting 4-bromotrifluorotoluene, the above items must be adhered to in order to effectively prevent risks and ensure the safety of personnel and the environment.