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What are the main uses of 4-Amino-2-Fluorobenzotrifluoride?
4-Amino-2-fluorotrifluorotoluene is a crucial intermediate in the field of organic synthesis. It has a wide range of uses and is often an indispensable raw material for the creation of new drugs in medicinal chemistry. Because fluorinated organic compounds often have unique physiological activities and metabolic stability, they can be used as a basis to develop drugs with good efficacy and small side effects.
In the field of pesticide chemistry, 4-amino-2-fluorotrifluorotoluene also plays a key role. With its chemical properties, many high-efficiency, low-toxicity and environmentally friendly pesticides can be synthesized to prevent and control pests and diseases, improve crop yield and quality.
Furthermore, in the field of materials science, functional materials synthesized from this raw material may have special optical and electrical properties, which can be applied to electronic devices, optical materials and many other fields.
In short, 4-amino-2-fluorotoluene has shown broad application prospects in many fields such as medicine, pesticides, and materials due to its unique chemical structure, and has made great contributions to promoting the development of various fields.
What are the physical properties of 4-Amino-2-Fluorobenzotrifluoride?
4-Amino-2-fluorotrifluorotoluene is an organic compound with unique physical properties. Its properties are white to off-white crystalline powder, which exists stably at room temperature and pressure.
The melting point is about 44-48 ° C. The melting point is the temperature at which a substance changes from a solid state to a liquid state. At this temperature, the molecule obtains enough energy to overcome the lattice energy, the lattice structure disintegrates, and the substance begins to melt into a liquid state. The melting point range of 4-amino-2-fluorotrifluorotoluene is relatively clear, which is of great significance for its separation, purification and identification in chemical production and scientific research experiments.
The boiling point is about 235-237 ° C. The boiling point is the temperature at which the saturated vapor pressure of the liquid is equal to the outside atmospheric pressure. At this time, the liquid is violently vaporized. Knowing the boiling point of the substance is crucial in separation operations such as distillation, and the appropriate temperature can be set accordingly to achieve separation from other substances with large boiling points.
In terms of solubility, it is slightly soluble in water, but easily soluble in most organic solvents, such as ethanol, ether, dichloromethane, etc. This is due to its molecular structure containing fluorine atoms and trifluoromethyl groups, which are highly electronegative and hydrophobic, making the molecular polarity different from water molecules and difficult to form hydrogen bonds with water; while organic solvent molecules are more similar to its polarity and are more soluble according to the principle of "similar miscibility".
The density is about 1.416g/cm ³. The density reflects the mass per unit volume of the substance. During storage, transportation and use, it can be used to calculate the relationship between its mass and volume, which is crucial for accurate access and packaging design.
In addition, the substance has a weak odor at room temperature and is relatively stable to air, but it is necessary to avoid contact with strong oxidants, strong acids, strong bases, etc., because it may undergo chemical reactions that affect its properties and purity. These physical properties lay the foundation for the application of 4-amino-2-fluorotrifluorotoluene in organic synthesis, pharmaceutical research and development, and other fields.
What are 4-Amino-2-Fluorobenzotrifluoride synthesis methods?
The synthesis of 4-amino-2-fluorotrifluorotoluene has different paths. First, it can be prepared by reduction of 2-fluoro-4-nitrotrifluorotoluene. In this process, metal and acid systems are often used as reducing agents, such as iron and hydrochloric acid. 2-fluoro-4-nitrotrifluorotoluene is placed in a suitable reactor, iron powder and hydrochloric acid are added, and the temperature is controlled and stirred. Iron reacts with hydrochloric acid to produce new hydrogen, and the nitro group can be gradually reduced to an amino group. After the reaction is completed, pure 4-amino-2-fluorotrifluorotoluene is obtained by separation and purification.
In addition, catalytic hydrogenation can also be used. Using 2-fluoro-4-nitrotrifluorotoluene as raw material, select suitable catalysts, such as palladium carbon, platinum carbon, etc. In an autoclave, fill with hydrogen to control temperature, pressure and time. Under this condition, hydrogen is hydrogenated with nitro groups under the action of catalysts, and nitro groups are converted into amino groups. After the reaction is completed, the catalyst is filtered off, distilled, etc., and the product can be obtained.
In addition, it can also go through the diazotization-reduction path. First, the aniline derivative containing the corresponding substituent is diazotized, and then the target product is obtained through the reduction step. For example, 2-fluoro-4- (trifluoromethyl) aniline is reacted with sodium nitrite and acid at low temperature to form a diazonium salt, and then the diazonium group is reduced to hydrogen with suitable reducing agents, such as stannous chloride, sodium sulfite, etc., and finally 4-amino-2-fluorotrifluorotoluene is obtained. Each method has its own advantages and disadvantages, and the actual application needs to be selected according to factors such as raw material availability, cost, and product purity requirements.
What 4-Amino-2-Fluorobenzotrifluoride need to pay attention to when storing and transporting
4-Amino-2-fluorotrifluorotoluene is an organic compound. When storing and transporting, the following matters should be paid attention to:
One is the storage conditions. This compound should be stored in a cool, dry and well-ventilated place. Because it may be more sensitive to heat, high temperature is easy to decompose or deteriorate, so it must be kept away from heat and fire sources. And it should be avoided from direct sunlight, which will damage the stability of the substance due to light or luminescent chemical reactions. The storage place should be kept away from oxidizing agents, acids, bases and other substances to prevent dangerous chemical reactions. For example, if it comes into contact with strong oxidizing agents, or causes violent oxidation reactions, or even fires and explosions.
The second is related to packaging. The packaging must be tight to ensure that there is no risk of leakage. Suitable packaging materials are commonly used, such as sealed glass bottles, plastic bottles or metal drums. The selected packaging material should not chemically react with the compound. Like some plastic materials, it may interact with the compound, resulting in package damage and material leakage. Therefore, careful selection is required.
The third is transportation requirements. During transportation, ensure that the container is stable, avoid collision and vibration, and prevent package damage. The means of transportation should also be kept dry, cool, and away from heat and fire sources. Transport personnel must be familiar with the characteristics of the compound and emergency treatment methods. If there is a leak and other situations, they can respond quickly and correctly.
The fourth is identification and documents. On storage containers and transportation packages, information such as the name, nature, and hazard warning of the compound should be clearly marked. At the same time, a complete chemical safety technical manual should be attached when transporting, so that relevant personnel can understand its characteristics, hazards and safety operation precautions.
In short, the storage and transportation of 4-amino-2-fluorotrifluorotoluene must strictly follow safety regulations and operating procedures to ensure the safety of personnel and the environment and avoid accidents.
What are the security risks associated with 4-Amino-2-Fluorobenzotrifluoride?
4-Amino-2-fluorotrifluorotoluene is an organic compound that is very important in the chemical and pharmaceutical synthesis fields. However, it has certain safety risks and needs to be treated with caution.
Toxicity, or potential hazards. Oral ingestion, inhalation or skin contact can be harmful to the human body. If inhaled its dust or vapor, it can irritate the respiratory tract, causing cough, asthma, shortness of breath, etc.; long-term or excessive exposure may damage the function of liver, kidney and other organs.
The risk of fire and explosion cannot be ignored. Although this compound is not extremely flammable, it may still burn in case of open flames and hot topics. And when it burns, it will release harmful gases such as fluoride and nitrogen, which will exacerbate the harm.
In addition, its chemical properties are active, and it is easy to react violently when it encounters strong oxidants, strong acids, strong bases and other substances, and even cause explosions. When storing and using, be sure to avoid mixing with such substances.
When handling 4-amino-2-fluorotrifluorotoluene, safety procedures must be strictly followed. Operators should wear protective clothing, protective gloves and goggles, etc., to ensure that respiratory protection is in place. The workplace should be well ventilated, with suitable fire equipment and leakage emergency treatment equipment. In the event of a leak, personnel should be evacuated quickly, the fire source should be cut off, and then appropriate treatment measures should be taken according to the leakage situation, such as absorbing with inert materials such as sand and vermiculite, or neutralizing with appropriate chemical reagents.