4 Acetylbenzotrifluoride
Fluoride

4-Acetylbenzotrifluoride

Duxiu Chemical

Specifications

HS Code

428742

Chemical Formula C9H7F3O
Molar Mass 188.15 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 210 - 212 °C
Density 1.265 g/cm³ (approximate)
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents like ethanol, ether
Vapor Pressure Low at room temperature
Flash Point 85 °C (closed cup)

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Packing & Storage
Packing 500g of 4 - Acetylbenzotrifluoride packaged in a sealed, corrosion - resistant container.
Storage 4 - Acetylbenzotrifluoride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials. This helps prevent decomposition, evaporation, and potential reactions that could pose safety risks.
Shipping 4 - Acetylbenzotrifluoride is shipped in specialized, well - sealed containers to prevent leakage. Due to its chemical nature, it follows strict hazardous materials shipping regulations, ensuring safe transportation.
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4-Acetylbenzotrifluoride
General Information
Historical Development
4-Acetyl trifluorotoluene is also an organic compound. Its traces can be traced back to the scientific research path of the past. At the beginning, the academic community began to explore fluoride-containing compounds, and many scholars devoted themselves to the synthesis of new fluorine-containing organic compounds.
At that time, Zhu Xian used benzene and fluorine-containing reagents as the basis to obtain this substance through several delicate reactions. The initial preparation method is complicated and ineffective, and it is only a small laboratory trial.
After the year, science and technology advanced day by day, and chemical technology was also revolutionized. The understanding of the new reaction mechanism and the improvement of the catalyst led to the simplification of the preparation process and the gradual increase in yield. From laboratory micro-test products to industrial mass production, it has emerged in various fields such as materials and medicine, and has become a key node in the development history of organic chemicals.
Product Overview
4-Acetyltrifluorotoluene is an important product of organic chemistry. Its appearance is colorless to light yellow liquid with a unique odor. This product is widely used in the field of organic synthesis and is often used as a key intermediate.
In terms of its chemical properties, the trifluoromethyl and acetyl groups of 4-acetyltrifluorotoluene give it special activity. The strong electron-absorbing properties of trifluoromethyl groups change the distribution of molecular electron clouds, affecting the reactivity and selectivity. Acetyl groups can participate in many classical organic reactions, such as nucleophilic addition and condensation.
In the synthesis process, it is mostly prepared by specific aromatics and reagents containing trifluoromethyl and acetyl groups under suitable catalysts and reaction conditions. Precise control of reaction conditions, such as temperature, solvent, catalyst dosage, etc., has a great impact on the yield and purity of the product.
Because of its unique properties, 4-acetyltrifluorotoluene has potential application value in the fields of medicine, pesticides, materials science, etc. It is a product that is valued in organic chemistry research and industrial production.
Physical & Chemical Properties
4 - Acetylbenzotrifluoride, organic compounds are also. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, it is a colorless to light yellow liquid with a special odor. Its boiling point is quite different, about 196-198 ° C, due to the intermolecular force. The melting point is also characteristic, about -15 ° C.
In terms of its chemical properties, in this compound, the benzene ring is connected to trifluoromethyl and acetyl groups, resulting in its unique chemical activity. The electron cloud density of the benzene ring is reduced by the electron-absorbing effect of trifluoromethyl, but the presence of acetyl groups has a certain electron supply effect, and the two check and balance each other. Therefore, it exhibits special reactivity and selectivity in the electrophilic substitution reaction. And its carbonyl group can participate in many reactions, such as addition to nucleophiles, and has a wide range of uses in the field of organic synthesis.
Technical Specifications & Labeling
Today, there is a thing called 4-acetyltrifluorotoluene. Its preparation method and characterization are related to technical regulations and are of great importance.
To make this thing, you need to follow a specific method. In the kettle, put a suitable material, control its temperature, observe the time, and follow the rules of chemistry to make all things fit together. After the reaction is completed, through various processes, such as fractionation and purification, pure 4-acetyltrifluorotoluene can be obtained.
Its characterization is also, judging its color, it should be a colorless or slightly yellow liquid, smelling it, with a specific gas. Measuring its boiling should be within a certain range; measuring its density, there is also a fixed number. This is the key to distinguish this product. According to these physical parameters, its authenticity can be distinguished, which is suitable for industrial use and should not be mistaken. In this way, it can be used in chemical preparation and practical applications without hindrance.
Preparation Method
The preparation method of 4-acetyltrifluorotoluene is related to the raw material and production process, reaction steps, and catalytic mechanism. The selection of raw materials is very critical, and the selection of specific organic reagents can be used to lay the foundation for subsequent reactions.
The reaction steps are rigorous and orderly, and a reactant is first integrated with the catalyst at a specific temperature and pressure. The catalytic mechanism is the core of the reaction. The selected catalyst has a unique activity check point, which can reduce the activation energy of the reaction and accelerate the reaction process.
The production process also needs to be carefully controlled. The precise regulation of temperature and pressure is related to the purity and yield of the product. During the reaction, the reaction process is closely monitored and the conditions are fine-tuned according to the actual situation. After the reaction is completed, high purity 4-acetyl trifluorotoluene is obtained by a series of separation and purification methods. In this way, the product can be efficiently prepared according to strict steps and delicate mechanisms.
Chemical Reactions & Modifications
Nowadays, there is a chemical substance called 4-acetyltrifluorotoluene. In the field of chemistry, reaction and modification are the key. The reaction of this compound requires detailed investigation of its characteristics.
The reaction conditions are very important. Temperature, humidity, and the choice of catalyst all affect the reaction process. To achieve the desired reaction effect, these factors must be precisely regulated. If the catalyst is not appropriate, the reaction may be slow, or the product may be impure.
As for modification, it is designed to optimize its performance. Or change its chemical structure to make it more stable, or increase its activity to meet diverse needs. After modification, or develop unique advantages in the fields of materials and medicine.
The study of the reaction and modification of this chemical product requires caution and scientific methods to seek its optimal state, which will contribute to the development of chemistry.
Synonyms & Product Names
4-Acetyl trifluorotoluene, this substance is widely used in the field of chemical industry. Its aliases and trade names also need to be explored in detail.
Guanfu ancient books and documents, the names of chemical substances often vary from time to place. 4-Acetyl trifluorotoluene, or another name, to meet the needs of different situations and industries. Its trade name is taken by merchants in recognition of its characteristics and uses to attract customers.
In the process of chemical research, knowing its aliases can help scholars read the books and not be fascinated by the change of name. Merchants use their trade names to make their products unique in the city. Therefore, it is clear that the synonyms and trade names of 4-acetyltrifluorotoluene are essential for academic research and commercial operation. Although the books do not contain the details of its synonyms and trade names, researchers can borrow various methods, such as checking the chemical books of the past dynasties and viewing the commercial directory of the world, to explore its details, for learning and business, it is beneficial.
Safety & Operational Standards
Safety and Operation Specifications for 4-Acetyltrifluorotoluene
Fu 4-acetyltrifluorotoluene is an important substance in chemical research. If you want to use this substance, you must first clarify its safety and operation specifications to avoid all kinds of hazards, ensure smooth experiments and personnel safety.
This substance has a certain chemical activity, or is active. Therefore, when storing, choose a cool, dry and well-ventilated place, away from fire and heat sources. If exposed to high temperature, or there is a risk of decomposition, and harmful gases will be generated. And it should be stored separately with oxidizing agents, reducing agents, etc., to prevent improper reactions and dangerous emergencies.
When taking it, strictly follow the operating procedures. Operators need to wear appropriate protective equipment, such as laboratory clothes, protective gloves, and wear goggles to prevent substances from splashing on the body and eyes, causing damage. When measuring, the action should be steady and accurate, and the container should be tightly covered with full speed to prevent its volatilization from escaping.
In the experimental operation room, ventilation devices must be operated regularly to drain harmful gases that may be generated. If 4-acetyltrifluorotoluene is involved in the reaction, you should be familiar with the reaction mechanism and possible side reactions first, and take precautions in advance. During the reaction process, pay close attention to temperature, pressure and other conditions, and take measures if there is any abnormality.
If there is unfortunately a substance leakage, do not panic. Small amounts of spills can be covered with inert materials such as sand and vermiculite. Carefully collect them in suitable containers and dispose of them properly. If a large amount of spills should be quickly evacuated, a warning area should be designated, and professional personnel should clean up with protective equipment.
When disposing of waste, it should not be ignored. Waste containing 4-acetyl trifluorotoluene must be collected in accordance with relevant regulations and handed over to qualified institutions for disposal. It is strictly forbidden to dump it at will to avoid polluting the environment.
In short, 4-acetyl trifluorotoluene is used in chemical research. Only by observing safety and operating practices can it achieve the purpose of research without risking safety and ensuring the safety of people and the environment.
Application Area
4-Acetyl trifluorotoluene, which has a wide range of uses. In the field of medicine, it can be used as a key intermediate to help create new drugs, treat specific diseases, and bring good news to patients. In the field of materials science, it can optimize material properties, such as improving material stability and durability, so that materials can be used for a longer time. In chemical synthesis, it is often an important raw material. Through various reaction paths, many high-value compounds are derived to meet different industrial needs. And it plays a significant role in the preparation of fine chemical products, adding product characteristics and improving quality. With its unique chemical properties, 4-acetyl trifluorotoluene has a non-negligible position in many application fields, promoting the development of related industries.
Research & Development
Today there is a product, named 4-Acetylbenzotrifluoride. I am a chemical researcher. I observe the characteristics of this product, study its development, and hope to gain something.
This product has unique chemical properties and has potential uses in chemical, pharmaceutical and other fields. I began to explore its synthesis method, seeking a high-efficiency and environmentally friendly path. After repeated tests, different raw materials and conditions are tested, with the aim of optimizing the synthesis process and improving the yield and purity.
In the research of application, it is found in pharmaceutical preparations, or can be used as a key intermediate to assist in the development of new drugs. It is also considered in materials science, or can give materials special properties.
I am well aware that the road to scientific research is long, but in order to pursue the development of this object, we must persevere and do our best to understand its more potential, promote its wide application, and contribute to the progress of various fields.
Toxicity Research
The study of chemistry is a big concern for people's livelihood. Now focus on 4 - Acetylbenzotrifluoride this thing, and investigate its toxicity in detail.
To observe its properties for the first time, in the experiment, all kinds of creatures are tested. Looking at the appearance of white mice, if they are exposed to the environment containing this thing for a long time, they will behave abnormally, or be impatient or tired, and their hair will lose its luster. The structure of its molecules is re-analyzed, which is in contact with the biochemical process in the body, which may disturb the order of metabolism and damage the ability of organs.
If this thing escapes from the outside and enters the water body, the aquatic things will also suffer from it. The propagation of algae is blocked, and the breath of fish and shrimp is endangered. Although it is not widely used in the world, it is highly toxic and cannot be ignored. In order to ensure the safety of all beings, it is urgent to study its detoxification methods and anti-leakage strategies.
Future Prospects
4-Acetyltrifluorotoluene, the future prospect of this product, concerns the hearts of our chemical researchers. Today's technology is advancing, and the application of this compound in various fields may have opportunities to emerge.
In pharmaceutical chemistry, it may be the key raw material for creating novel and specific drugs, helping doctors overcome difficult diseases and preventing all living beings from suffering. In the field of materials science, it is expected to give birth to new materials with excellent performance, opening a new chapter for equipment manufacturing, construction and other industries.
Although there may be thorns in the road ahead, we chemists should move forward with enthusiasm for exploration. We hope to make unremitting efforts to reveal more potential of 4-acetyl trifluorotoluene, add a splendid color to the future world, and create infinite well-being.
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Frequently Asked Questions

As a leading 4-Acetylbenzotrifluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Acetylbenzotrifluoride?
4-Acetyl trifluorotoluene has a wide range of main uses. In the field of organic synthesis, it is a crucial intermediate. It can be converted into a wide variety of compounds through many chemical reactions, such as the synthesis of drugs, pesticides and functional materials with special properties.
In the field of pharmaceutical creation, with its unique chemical structure, it can help synthesize new drug molecules. Due to the existence of trifluoromethyl and acetyl groups, the molecules are endowed with special physical and chemical properties, such as improving the lipid solubility, stability and biological activity of drugs. This is of great significance for improving the efficacy of drugs and reducing toxic and side effects.
In the field of pesticide development, 4-acetyltrifluorotoluene is also indispensable. It can be used as a key raw material for the preparation of high-efficiency, low-toxicity and environmentally friendly pesticide varieties. Due to its structural characteristics, it may endow pesticides with excellent insecticidal, bactericidal or weeding properties, which helps to improve the yield and quality of crops, and has little negative impact on the environment.
In the field of materials science, it can be used to synthesize materials with special functions. For example, by introducing this compound, the material may have unique optical, electrical or thermal properties, which can be applied to fields such as optoelectronic materials, polymer materials, etc., to meet the special needs of material properties in different scenarios. In conclusion, 4-acetyltrifluorotoluene, with its unique chemical structure, plays a pivotal role in many fields such as organic synthesis, medicine, pesticides, and materials science, promoting sustainable development and innovation in various fields.
What are the physical properties of 4-Acetylbenzotrifluoride?
4-Acetyl trifluorotoluene is one of the organic compounds. Its physical properties are quite impressive.
Looking at its appearance, at room temperature, it often takes the form of a colorless to light yellow liquid, which is clear and has a special appearance. Its smell is irritating to a certain extent, and its unique smell can be sensed by smelling.
When it comes to boiling point, it is about 220-222 ° C. The boiling point is the critical temperature at which a substance changes from liquid to gaseous state. This boiling point value reflects the state of intermolecular forces, so that the substance can achieve phase transformation at the corresponding temperature.
As for the melting point, it is about -28 ° C. The melting point is the temperature limit of the solid state to the liquid state. Under this temperature, the substance survives as a solid state, and gradually melts into a liquid state beyond this temperature.
Its density is about 1.28g/cm ³, and the density is also the mass per unit volume of the substance. This value shows that under the same volume, the substance is heavier than water, and it needs to be properly disposed of according to this characteristic in practical application and storage.
In terms of solubility, 4-acetyltrifluorotoluene is insoluble in water, but it has good solubility in many organic solvents, such as ethanol, ether, acetone, etc. This property is due to the interaction between its molecular structure and the molecules of organic solvents, such as van der Waals force, hydrogen bonding, etc., which makes it easy to mix and integrate with each other. And its insolubility in water is due to the strong hydrogen bonding between water molecules, and the weak interaction between the molecules of this substance and water molecules, making it difficult to break the tight structure between water molecules and dissolve into it.
These physical properties are of great significance in many fields such as organic synthesis and materials science. In organic synthesis, according to its boiling point, solubility, etc., suitable reaction conditions and separation and purification methods can be selected; in materials science, its physical properties may affect the properties and applications of materials.
What is the chemistry of 4-Acetylbenzotrifluoride?
4-Acetyltrifluorotoluene has different chemical properties. This substance contains acetyl and trifluoromethyl groups, so it has unique properties.
Acetyl groups have the ability to nucleophilic addition. Carbon in carbonyl is positively electrically active and easy to be attacked by nucleophilic reagents. If it is catalyzed by acids with alcohols, it can form acetals. Taking ethanol as an example, under the condition of appropriate amount of p-toluenesulfonic acid catalysis and heating reflux, the corresponding acetal product can be obtained. This is obtained by the attack of carbonyl carbon by solitary electrons on the oxygen of the alcohol, which is obtained by proton transfer and dehydration.
Trifluoromethyl has strong electron absorption. This property reduces the density of the electron cloud of the benzene ring and reduces the activity of the electrophilic substitution reaction of the benzene ring. In terms of nitrification, compared with benzene, the reaction conditions are more severe, requiring stronger nitrifying reagents and higher temperatures. And because of its electron-absorbing effect, the density of the ortho and para-position electron clouds decreases more than that of the meta-position, so electrophilic substitution tends to meta-position.
And because of its fluoride content, the molecule has high stability and low surface energy. In organic synthesis, this structure can be introduced to modify the chemical and physical properties of the product, such as improving thermal stability and chemical inertness. In the field of materials, it can be used to make water-repellent and oil-repellent materials. Due to low surface energy, the surface tension can be reduced, making it difficult for water and oil to adhere.
In addition, the carbonyl group of 4-acetyltrifluorotoluene can be reduced. Using lithium aluminum hydride as a reducing agent, in anhydrous ether and other inert solvents, carbonyl groups can be reduced to alcohol hydroxyl groups to obtain 4- (1-hydroxyethyl) trifluorotoluene. If sodium borohydride is used as a reducing agent, its selectivity is better. Generally, only carbonyl groups are reduced, which has little effect on other functional groups in the molecule. The conversion of carbonyl groups to alcohol hydroxyl groups is often achieved under milder conditions.
What is 4-Acetylbenzotrifluoride production method?
The preparation method of 4-acetyltrifluorotoluene is an important topic in the field of organic synthesis. In the past, the common methods for preparing this compound are as follows.
First, trifluorotoluene is used as the starting material. Shilling trifluorotoluene reacts with acetylating reagents, such as acetyl chloride or acetic anhydride, under the action of a catalyst. This catalyst commonly uses Lewis acids such as anhydrous aluminum trichloride. During the reaction, the benzene ring of trifluorotoluene is attacked by acetyl groups. Through electrophilic substitution, acetyl groups are introduced at specific positions in the benzene ring to obtain 4-acetyltrifluorotoluene. This process requires attention to the control of reaction temperature, reagent ratio and reaction time. If the temperature is too high, it may cause multiple substitution side reactions; the proportion of reagents is improper, which also affects the yield. And anhydrous aluminum trichloride is sensitive to water vapor and needs to be operated in an anhydrous environment.
Second, it can be started from benzene derivatives containing specific substituents. For example, select a suitable trifluoromethyl substituted benzene, which has a group that can be converted into an acetyl group on its benzene ring. After multi-step reaction, such as proper protection of the group first, and then a series of reactions such as oxidation and substitution, the acetyl group structure is gradually constructed, and finally 4-acetyl trifluorotoluene is obtained. Although this path has many steps, it can flexibly control the reaction of each step, introduce the required group accurately, and improve the purity of the product. However, each step of the reaction needs to be carefully designed and operated to reduce side reactions and ensure the efficiency of the overall synthesis route.
Or there may be other innovative synthesis methods emerging, but the above two are more traditional and common ways to prepare 4-acetyltrifluorotoluene, each with its own advantages and disadvantages. In practical applications, they are selected according to specific needs and conditions.
What are the precautions in storage and transportation of 4-Acetylbenzotrifluoride?
4-Acetyl trifluorotoluene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage, this compound should be placed in a cool, dry and well-ventilated place. Cover because it is easy to cause chemical reactions when heated, which damages quality, so it is important to avoid heat. A cool place can keep its chemical properties stable. A dry place to prevent moisture from invading, due to moisture or causing its hydrolysis and other adverse reactions. Well ventilated, it can avoid the accumulation of gas and reduce the risk of safety.
Furthermore, when storing, it should be separated from oxidants, reducing agents, alkalis and other substances. The chemical activity of 4-acetyltrifluorotoluene, in case of such substances, may cause violent reactions, causing danger. And the storage container must be sealed to prevent it from volatilizing and escaping, causing the loss of ingredients, and avoiding it from reacting with other substances in the air.
As for transportation, be sure to ensure that the packaging is intact. The packaging material must be strong and durable, and can resist vibration and collision during transportation. And the transportation vehicle should be equipped with corresponding fire protection and leakage emergency treatment equipment. If there is a leak on the way, it can be dealt with in time to reduce the damage. During transportation, it should also avoid high temperature and open flames, drive according to the specified route, and stay away from densely populated areas to ensure safety.
In conclusion, 4-acetyltrifluorotoluene has strict requirements for the environment, isolation from other objects, and packaging and transportation conditions during storage and transportation, so as to ensure its safety and quality.