3-Iodo-4-Aminobenzotrifluoride

3-Iodine-4-aminotrifluorotoluene, which has a wide range of uses, is often used as a key intermediate in the field of medicinal chemistry to create many specific drugs. For example, in the development of anti-cancer drugs, its structural characteristics can participate in the construction of drug molecules. Through specific chemical reactions, it is connected with other chemical groups to shape a molecular structure with precise targeting and high anti-cancer activity.
In the field of materials science, it also has its uses. Or it can be used as a raw material for the synthesis of functional materials, giving materials special optical and electrical properties. For example, the synthesis of materials with special photoelectric conversion properties can be used in new photoelectric devices, such as high-efficiency solar cells, to improve the photoelectric conversion efficiency.
In the field of organic synthetic chemistry, it is a commonly used building block. With its activity of iodine atoms and amino groups, complex organic molecular structures are constructed through various organic reactions, such as coupling reactions, substitution reactions, etc., providing a foundation for the synthesis of novel organic compounds, expanding the types and properties of organic compounds, and promoting the development of organic synthetic chemistry. In short, 3-iodine-4-aminotrifluorotoluene plays an indispensable role in many important fields, contributing to technological innovation and Product Research & Development in related fields.

3-Iodine-4-aminotrifluorotoluene is an important compound in organic chemistry. Its physical properties are quite worthy of investigation.
First of all, its appearance, under room temperature and pressure, this material is mostly white to light yellow crystalline powder, delicate and with a certain luster, like fine sand deposited over time, quiet and unique.
As for the melting point, it is about 55-59 ° C. Just like the temperature of the warm sun melting snow in spring, within this specific temperature limit, the solid 3-iodine-4-aminotrifluorotoluene gradually melts into a liquid state, the intermolecular binding is slightly looser, and the agility is increased.
In terms of boiling point, it is roughly 265-267 ° C. When the temperature rises to this point, the molecular energy increases sharply, breaking free from the shackles of the liquid phase, and turning into a gaseous state to soar in space, like Kunpeng skyrocketing 90,000 miles.
Density is also an important physical property, about 1.84 g/cm ³, compared to the density of common water of 1 g/cm ³, it is more dense, like a thick rock, stable and solid.
In terms of solubility, it is slightly soluble in water, just like a guest in water, and it is difficult to completely blend. However, in organic solvents, such as ethanol, ether, dichloromethane, etc., it can be better dissolved, just like fish entering rivers and shuttling freely.
In addition, the chemical properties of this compound are relatively stable under normal conditions. When encountering strong oxidants, strong acids, strong bases, etc., chemical reactions will also occur, just like throwing boulders into a calm lake, creating layers of ripples. Its stability and reactivity together constitute the unique "character" of 3-iodine-4-aminotrifluorotoluene in the chemical world, and play a key role in many fields such as organic synthesis.

The synthesis method of 3-iodine-4-aminotrifluorotoluene covers a variety of paths.
One of them can be obtained from 4-aminotrifluorotoluene through iodine substitution reaction. In this reaction, an appropriate iodine substitution reagent, such as iodine element ($I_ {2} $), is combined with an appropriate oxidant, such as hydrogen peroxide ($H_ {2} O_ {2} $) or nitric acid ($HNO_ {3} $). Under suitable reaction conditions, such as in a suitable solvent, control the temperature and reaction time to cause the amino ortho-site to undergo iodine substitution. The selected solvent can be acetic acid, etc., which can promote the reaction and have good solubility to the substrate and the reagent. The temperature may need to be controlled in a mild range, between about 0-50 ° C, depending on the specific reagent activity and reaction process. In this way, the conversion of 4-aminotrifluorotoluene to 3-iodine-4-aminotrifluorotoluene can be achieved through an electrophilic substitution mechanism.
Second, the target product can also be constructed by multi-step reaction from aromatic hydrocarbons containing suitable substituents. For example, the introduction of trifluoromethyl groups first can be achieved by the reaction of aromatic hydrocarbons with trifluoromethylation reagents, such as the use of Grignard reagents such as trifluoromethyl halide magnesium, or the use of Ullmann reaction and other methods to introduce trifluoromethyl groups on aromatic hydrocarbons. Then, nitro groups are introduced through nitration reaction, and then the nitro groups are converted into amino groups by reduction, and finally the iodine substitution reaction is carried out. Although this route has many steps, the reaction conditions of each step can be flexibly adjusted to optimize the yield and purity of the product. Each step requires fine control of conditions, such as the ratio of nitric acid to sulfuric acid in the nitration reaction, the reaction temperature, the selection and dosage of reducing agents in the reduction reaction, and the reagents and solvents in the iod
Third, there is still a way to use halogenated aromatics as starting materials to construct structures containing trifluoromethyl and amino groups through metal-catalyzed coupling reactions. If a suitable halogenated aromatic hydrocarbon and a trifluoromethylation reagent are coupled under palladium catalysis, trifluoromethyl is introduced, and then amino and iodine atoms are introduced in turn through subsequent reactions. In this process, the activity of metal catalysts and the selection of ligands are crucial, which will significantly affect the selectivity and efficiency of the reaction. And proper separation and purification are required after each step of the reaction to ensure the purity of the subsequent reaction substrate, and finally 3-iodine-4-amino trifluorotoluene is successfully synthesized.

3-Iodine-4-aminotrifluorotoluene is an organic compound. When storing and transporting, the following matters must be paid attention to:
First, when storing, it should be placed in a cool, dry and well-ventilated place. This compound is easy to decompose and deteriorate when heated, so it should be kept away from fire and heat sources, and must not be placed in direct sunlight. A dry environment can prevent it from affecting the quality due to moisture absorption, and good ventilation can avoid the accumulation of harmful gases.
Second, it must be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because of its active chemical properties, contact with the above substances can easily cause chemical reactions, and even may lead to serious accidents such as combustion and explosion.
Third, the storage container must be made of suitable materials and ensure that it is well sealed. Generally speaking, containers made of glass, stainless steel and other materials can be selected, which can not only prevent it from reacting with the container, but also effectively prevent leakage.
Fourth, during transportation, ensure that the container is stable and free from collision and vibration, so as to avoid leakage caused by damage to the container. It is necessary to strictly follow the relevant regulations on the transportation of hazardous chemicals, and be equipped with necessary emergency treatment equipment and protective equipment.
Fifth, people who operate and come into contact with this compound must undergo professional training and be familiar with its physical and chemical properties and safety precautions. When working, protective clothing, gloves, goggles and other protective equipment should be worn to prevent contact with the skin and eyes. In case of inadvertent contact, correct emergency measures should be taken immediately.
In short, the storage and transportation of 3-iodine-4-aminotrifluorotoluene must strictly follow the relevant specifications and requirements, and be handled carefully to ensure the safety of personnel and the environment is not polluted.

The market price range of 3-iodine-4-aminotrifluorotoluene is difficult to say exactly. The price of this chemical often fluctuates widely due to various factors.
First, the price and availability of raw materials are crucial. If the raw materials required for its synthesis are in short supply or prices surge due to poor production, market monopoly or other reasons, the cost of 3-iodine-4-aminotrifluorotoluene will also rise, which will then push up its market price.
Second, the difficulty of the preparation process is closely related to the cost. If the synthesis of this compound requires complicated steps, special reaction conditions or expensive catalysts, it will undoubtedly increase the production cost, and its market price will also rise.
Third, the market supply and demand situation determines the price. If the market demand for this compound is strong and the supply is limited, merchants may increase the price due to shortage; conversely, if the demand is low and the supply exceeds the demand, the price may decline.
Fourth, the scale of the manufacturer and the operating cost also have an impact. Large-scale manufacturers may reduce the unit cost due to the scale effect, and the price may be more competitive; while small manufacturers have high operating costs and their product pricing may be relatively high.
In addition, factors such as regional differences, transportation costs, and international trade policies will also vary prices in different regions.
In summary, the market price of 3-iodine-4-aminotrifluorotoluene ranges from a few yuan per gram to several hundred yuan per gram, which is difficult to accurately define and depends on the specific market environment and transaction details.