3-Cyano-2-Fluorobenzotrifluoride~ Alpha, Alpha, Alpha, what is the main use of 2-Tetrafluoro-M-Tolunitrile
3-Cyano-2-fluorotrifluorotoluene, also known as α, α, α, 2-tetrafluoro-m-toluonitrile, is widely used. In the field of pharmaceutical synthesis, it is often used as a key intermediate to help develop new drugs. The molecular structure of Gain contains special functional groups, which can participate in a variety of chemical reactions. By carefully designing the reaction path, complex and biologically active compound structures can be constructed, which is of great significance in the process of creating specific drugs such as anti-virus and anti-tumor.
In the field of materials science, it is also of great value. Due to the properties of fluorine atoms, it can endow materials with excellent properties such as chemical resistance, low surface energy, and excellent thermal stability. For example, when adding high-performance coatings and special plastics, the material quality and application range can be greatly improved, meeting the strict requirements of high-end fields such as aerospace and electronics.
Furthermore, in the field of pesticide chemistry, 3-cyano-2-fluorotrifluorotoluene can be used to synthesize high-efficiency and low-toxicity pesticides. With its unique chemical structure, the synthesized pesticides can act more accurately on target organisms, improve drug efficacy, and reduce harm to non-target organisms and the environment, in line with the trend of modern green agriculture.
To sum up, 3-cyano-2-fluorotrifluorotoluene, with its unique chemical structure, plays an important role in many fields such as medicine, materials, and pesticides, and has far-reaching significance in promoting the development of related industries.
What are the physical properties of 3-Cyano-2-Fluorobenzotrifluoride~ Alpha, Alpha, Alpha, 2-Tetrafluoro-M-Tolunitrile
3-Cyano-2-fluorotrifluorotoluene, also known as α, α, α, 2-tetrafluoro-m-toluonitrile, has unique physical properties. It is a colorless to light yellow liquid, which is clear and transparent in appearance. Under normal conditions, it is in a flowing state and feels as smooth as water.
From the melting point, it is between -30 ° C and -20 ° C. Within this temperature limit, the substance gradually melts from solid to liquid. In terms of boiling point, it is roughly in the range of 160 ° C to 170 ° C. At this temperature, the liquid will transform into a gaseous state.
Its density is heavier than water, about 1.4-1.5g/cm ³. If mixed with water, it will sink underwater. And the substance is insoluble in water, but easily soluble in common organic solvents, such as dichloromethane, chloroform, toluene, etc., which can be uniformly dispersed in these solvents to form a uniform solution.
Its vapor pressure is low at room temperature, its volatility is relatively weak, and it is relatively stable in air. It is not easy to evaporate and dissipate rapidly. In addition, its refractive index has a specific value, about 1.4-1.5. When light passes through, it will produce a corresponding refraction phenomenon. This property is quite meaningful in optical correlation detection and analysis.
These physical properties play a key role in the rational application of 3-cyano-2-fluorotrifluorotoluene in many fields such as chemical synthesis and material preparation. Relevant practitioners can accurately control its use conditions and operation procedures according to these properties.
3-Cyano-2-Fluorobenzotrifluoride~ Alpha, Alpha, Alpha, 2-Tetrafluoro-M-Tolunitrile are chemically stable?
3-Cyano-2-fluorotrifluorotoluene, also known as α, α, α, 2-tetrafluoro-m-toluonitrile, its chemical properties are stable under common conditions.
In this compound, the cyano group (-CN) is connected to the benzene ring, and the cyano group is relatively stable chemically and can participate in nucleophilic substitution and addition reactions. However, due to the influence of the benzene ring and trifluoromethyl, the reactivity is limited. The fluorine atom (-F) is connected to the benzene ring, and the electronegativity of the fluorine atom is extremely high, which can reduce the electron cloud density of the benzene ring by induction effect, thereby reducing the electrophilic substitution reaction activity of the benzene ring, Trifluoromethyl (-CF) is also connected to the benzene ring, which has strong electron-withdrawing properties, which not only affects the electron cloud distribution of the benzene ring, but also enhances the lipid solubility and stability of the molecule.
Under normal environmental conditions, such as room temperature and pressure without specific catalysts or reaction conditions, the compound can maintain its own chemical structure for a long time and does not easily react spontaneously. However, under specific chemical reaction conditions, such as high temperature, strong acid-base environment or the presence of specific catalysts, cyanyl groups can be hydrolyzed to carboxyl groups, or participate in cyclization reactions; benzene rings can also undergo electrophilic substitution reactions such as halogenation and nitrification under suitable conditions.
Overall, 3-cyano-2-fluorotrifluorotoluene is chemically stable under normal conditions, but specific conditions can still trigger a variety of chemical reactions.
What is the preparation method of 3-Cyano-2-Fluorobenzotrifluoride~ Alpha, Alpha, Alpha, 2-Tetrafluoro-M-Tolunitrile
3-Cyano-2-fluorotrifluorotoluene (3-Cyano-2-Fluorobenzotrifluoride), also known as α, α, α, 2-tetrafluoro-m-toluonitrile (Alpha, α, α, 2-Tetrafluoro-M-Tolunitrile), is prepared as follows:
can usually be reacted from the corresponding halogenated aromatic hydrocarbon. Using m-fluorotoluene as the starting material, the cyanation reaction is first carried out. Under appropriate reaction conditions, such as in the presence of a catalyst, a nucleophilic substitution reaction occurs with a cyanide reagent (such as potassium cyanide, etc.), so that the methyl ortho-position is introduced into the cyano group to generate 2-cyano-3-fluorotoluene. This step needs to be carried out in a suitable solvent system, such as N, N-dimethylformamide (DMF), and the reaction temperature and reaction time should be strictly controlled to ensure the selectivity and yield of the reaction.
Subsequently, the obtained 2-cyano-3-fluorotoluene is subjected to trifluoromethylation. Generally, fluorine-containing reagents, such as trifluoromethylation reagents (such as sodium trifluoromethanesulfonate, etc.), are used to convert the methyl groups on the benzene ring into trifluoromethyl groups under alkaline conditions and specific catalysts, so as to obtain 3-cyano-2-fluorotrifluorotoluene. In this process, the strength of basic conditions, the type and amount of catalysts, as well as the temperature and time of the reaction have a significant impact on the process of the reaction and the purity of the product.
Another possible method is to use m-bromo (or m-chloro) trifluorotoluene as the starting material, first through a metal reagent (such as magnesium reagent to generate Grignard reagent), and then react with a cyanylation reagent (such as cuprous cyanide, etc.) to introduce a cyanyl group. At the same time, the fluoride reaction is carried out to control the reaction conditions, so that fluorine atoms are introduced at specific positions on the benzene ring, and finally the target product 3-cyano-2-fluorotrifluorotoluene is obtained. The entire preparation process requires precise control of the reaction conditions at each step to ensure that the reaction proceeds smoothly and a higher purity product is obtained.
3-Cyano-2-Fluorobenzotrifluoride~ What is the price range of Alpha, Alpha, Alpha, 2-Tetrafluoro-M-Tolunitrile in the market?
I look at your question and ask about the market price range of 3-cyano-2-fluorotrifluorotoluene (ie α, α, α, 2-tetrafluoro-m-toluonitrile). However, the price of this chemical is difficult to determine, and it is affected by many factors.
First, the situation of market supply and demand is due to factors. If there is a large number of people in demand, and the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price may fall. Second, the cost of raw materials is also related to the price. If the raw materials required for its preparation are expensive, the price of the finished product will also be high; if the raw materials are easy to obtain and cheap, the price of the product may be reduced. Third, the production process and difficulty also have an impact. If the preparation process is complicated, the technical requirements are high, and the manpower and material resources are consumed, the price will be high; if the process is simple, the price may be slightly lower.
Furthermore, different suppliers set different prices due to their own operating costs and market strategies. When purchasing on a large scale, you may get a preferential price; and if you buy a small amount, the price may be higher. And the market price often fluctuates over time, and economic conditions, policies and regulations and other factors can change it.
In my opinion, if you want to know the exact price range, you should consult chemical product suppliers, distributors, or refer to the quotations of chemical product trading platforms. This way, you can obtain more accurate price information to meet your needs.