What is the main use of 3-chloro benzotrifluoride?

3-Chlorotrifluorotoluene has a wide range of main uses. In the field of organic synthesis, it can be called an extremely critical intermediate. Due to its unique structure, a wide range of organic compounds can be derived through many chemical reactions.

In the preparation of medicine, this compound is often an important starting material. After a series of delicate reaction steps, it can be converted into substances with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs, 3-chlorotrifluorotoluene plays an indispensable role. By ingeniously combining with other reagents, the core structure of the drug is carefully constructed, and then the drug is endowed with excellent antibacterial effect.

In the field of pesticides, it also plays a pivotal role. It can be used as a key component in the synthesis of new pesticides. Thanks to its special chemical properties, the prepared pesticides have shown extraordinary effectiveness in the control of crop diseases and pests. For example, pesticides synthesized based on 3-chlorotrifluorotoluene for specific pests can precisely act on the physiological system of pests, effectively inhibit the reproduction and invasion of pests, ensure the growth of crops, and improve food yield and quality.

In the field of materials science, 3-chlorotrifluorotoluene has also emerged. It can be used to prepare polymer materials with excellent performance. In the polymerization process, its participation in the reaction can significantly improve the properties of materials, such as improving the chemical resistance and heat resistance of materials. Polymer materials made from it are often used in high-end industrial fields, such as aerospace components, special chemical equipment, etc., and meet strict application requirements with excellent properties.

In addition, in the synthesis of dyes, 3-chlorotrifluorotoluene also plays an important role. It can introduce unique structural fragments into dye molecules, endow dyes with richer colors and excellent dyeing properties, making it widely used in textile printing and dyeing industries, adding brilliant colors to people's lives. In short, 3-chlorotrifluorotoluene has important uses in many fields, promoting the continuous development and progress of related industries.

What are the physical properties of 3-chloro benzotrifluoride

3-Chlorotrifluorotoluene, its physical state is a colorless to light yellow liquid at room temperature, and the smell is irritating, like a spicy taste. Looking at its color, it looks like clear water, but it is slightly yellowish and shiny, and it can be seen shining in the sun.

The boiling point of this substance is about 187-188 ° C, just like water rises to the boiling point. At this temperature, 3-chlorotrifluorotoluene also turns from liquid to gaseous. The melting point is very low, about -36 ° C., such as the extreme cold of a cold winter, at this low temperature, it solidifies into a solid state.

Its density is greater than that of water, about 1.388g/cm ³. If it is placed in one place with water, such as a stone sinking to the bottom of the water, it will sink to the bottom of the water. And insoluble in water, the two meet, just like oil and water, distinct and independent.

3-chlorotrifluorotoluene can be miscible with organic solvents such as ethanol and ether, such as wine and wine, and the two blend seamlessly. Its vapor is heavier than air, sinking like a thick fog, and spreading close to the ground. < Br >
This substance is widely used in the chemical industry. It is a key raw material for the synthesis of many fine chemicals, such as dyes, medicines, pesticides, etc. It is indispensable, just like masonry in high-rise buildings. However, it should be noted that it has certain toxicity and irritation. When operating, it must be carefully protected to prevent injury.

What are the chemical properties of 3-chloro benzotrifluoride

3-Chloro-trifluorotoluene, which is a colorless and transparent liquid with a special odor. The chemical properties of this substance are unique and have the following numbers.

First of all, its chemical stability. In the molecular structure of 3-chloro-trifluorotoluene, trifluoromethyl has strong electronegativity, which causes uneven distribution of molecular electron clouds, which enhances its chemical stability. Under many common conditions, it is not easy to decompose or other spontaneous reactions on its own, and can be stored stably for a long time at room temperature and pressure.

Furthermore, its halogenated aromatic hydrocarbon characteristics are remarkable. The chlorine atom in the molecule gives it the typical properties of halogenated aromatics. When encountering nucleophiles, chlorine atoms can be replaced. If it reacts with sodium alcohol under suitable conditions, the chlorine atom may be replaced by an alkoxy group to form the corresponding ether compound. The activity of this substitution reaction is affected by the electron-withdrawing action of trifluoromethyl. Trifluoromethyl reduces the density of the benzene ring electron cloud, making it easier for the chlorine atoms to leave, and nucleophilic substitution reactions are more likely to occur than general chloroaromatic hydrocarbons.

In addition, 3-chloro-trifluorotoluene has a special performance in the aromatic electrophilic substitution reaction. Trifluoromethyl is a strong electron-withdrawing group, which decreases the density of the benzene ring electron cloud and weakens its attractiveness to electrophilic reagents, so its electrophilic sub And during the reaction, the substituent mainly enters the intersite of the chlorine atom. Due to the combined effect of trifluoromethyl and the electron effect of the chlorine atom, the density of the intersite electron cloud is relatively high, which is more conducive to the attack of electrophilic reagents.

In the redox reaction, 3-chloro-trifluorotoluene is relatively stable and is not easily acted by common weak oxidants or reducing agents. However, in the case of strong oxidants, such as reacting with strong oxidation reagents such as potassium permanganate under specific conditions, the benzene ring may be oxidized to open the ring and form oxidation products such as fluorine-containing carboxylic acids.

In short, 3-chloro-trifluorotoluene is widely used in organic synthesis due to its unique molecular structure and chemical properties, including both halogenated aromatics and the existence of trifluoromethyl. In-depth investigation of its chemical properties will help to better exert its effectiveness.

What is the production method of 3-chloro benzotrifluoride?

3-Chlorotrifluorotoluene, also known as m-chlorotrifluorotoluene, is prepared as follows:

###Using m-chlorobenzoic acid as raw material
1. ** Reaction principle **: m-chlorobenzoic acid interacts with a fluorinating agent, and the carboxyl group is converted to trifluoromethyl.
2. ** Operation process **: Place m-chlorobenzoic acid in a reactor and add an appropriate amount of fluorinated reagents, such as the mixed system of trifluoroacetic anhydride and hydrogen fluoride. Under a certain temperature and pressure, open stirring to react. In the reaction, the fluorine atom of the fluorinated reagent gradually replaces the related atom on the carboxyl group, and generates 3-chlorotrifluorotoluene through a series of complex reactions. After the reaction is completed, the reaction liquid is cooled, and then the crude product of 3-chlorotrifluorotoluene is separated by distillation, and then the high-purity product is obtained by refining operations such as distillation. The reaction conditions of this method are relatively mild, but the cost of the raw material m-chlorobenzoic acid is higher.

###Using m-chlorotoluene as raw material
1. ** Reaction principle **: Introduce chlorine atoms at the ortho-site of benzene cyclomethyl through halogenation reaction, then oxidize the methyl group to a carboxyl group, and finally convert the carboxyl group to trifluoromethyl.
2. ** Operation process **: First put m-chlorotoluene into the reaction vessel, add an appropriate catalyst such as iron-based catalyst, introduce chlorine gas, and carry out chlorination reaction under light or heating conditions to generate 3-chloro-4-chloromethyltoluene. Subsequently, the product is reacted with a strong oxidant such as potassium permanganate, etc., at a suitable temperature and pH conditions, the methyl group is oxidized to a carboxyl group to obtain 3-chloro-4-carboxychlorobenzene. Finally, as in the above-mentioned step of using m-chlorobenzoic acid as a raw material, the carboxyl group is converted to trifluoromethyl using a fluorinating agent, and 3-chlorotrifluorotoluene is obtained by cooling, separation, and refining. The raw materials for this route are relatively easy to obtain, but there are many reaction steps, and the overall yield may be affected.

###Using m-amino trifluorotoluene as raw material
1. ** Reaction principle **: The amino group is converted into a leavable group by diazotization reaction, and then replaced by a chlorine atom.
2. ** Operation process **: In a low temperature environment, the m-amino trifluorotoluene is dissolved in a suitable acid solution such as hydrochloric acid, and the sodium nitrite solution is added dropwise for diazotization reaction to generate a diazonium salt. After that, a catalyst such as cuprous chloride and an appropriate amount of chlorination agent are added to the system, and the diazonium group is replaced by a chlorine atom to generate 3-chlorotrifluorotoluene. After the reaction is completed, the product is separated and purified by extraction, distillation and other steps. The reaction steps of this method are relatively simple, but the raw material cost of m-amino trifluorotoluene is relatively high, and the diazotization reaction needs to strictly control the reaction conditions to prevent safety accidents.

What are the precautions for 3-chloro benzotrifluoride in storage and transportation?

For 3-chlorotrifluorotoluene, many things need to be paid attention to during storage and transportation. This is an organic compound with certain chemical activity and danger, so it must be handled with caution.

When storing, the first environmental conditions. It should be placed in a cool and well-ventilated place, away from fire and heat sources. Because it is flammable, it can cause the risk of combustion and explosion in case of open flames and hot topics, so the source of fire must not be accessible. The temperature of the warehouse should be controlled within a suitable range to prevent excessive temperature from causing its volatilization to intensify or triggering other chemical reactions.

In addition, the choice of storage container is also critical. A well-sealed container must be used to prevent its leakage. Because it is irritating to the respiratory tract, eyes and skin, once it leaks, it not only pollutes the environment, but also endangers the safety of personnel. The material of the container used should be able to withstand its chemical corrosion to avoid leakage accidents caused by damage to the container.

During transportation, there are also many key points. Transportation vehicles must meet safety standards and be equipped with corresponding fire equipment and leakage emergency treatment equipment. When loading and unloading, operators must strictly follow the operating procedures, pack and unload lightly to prevent damage to the container. During transportation, avoid sun exposure, rain exposure, and do not mix with oxidants, acids, alkalis, etc., because violent chemical reactions with these substances may occur, causing danger.

In short, the storage and transportation of 3-chlorotrifluorotoluene must be carried out in strict accordance with safety regulations, and must not be slack, so as to ensure the safety of personnel and the environment from harm.