As a leading 3-Bromo-4-Fluoro-5-Nitrobenzotrifluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 3-Bromo-4-Fluoro-5-Nitrobenzotrifluoride?
3-Bromo-4-fluoro-5-nitrotrifluorotoluene, an organic compound, has unique chemical properties and is worthy of detailed investigation.
Looking at its structure, bromine (Br), fluorine (F), nitro (NO ²) and trifluoromethyl (CF 🥰) are attached to the benzene ring. Bromine atoms have certain electronegativity, which can change the electron cloud density of the benzene ring. In the nucleophilic substitution reaction, bromine can be used as a leaving group and is easily replaced by nucleophilic reagents. For example, in the case of strong nucleophilic reagents such as sodium alcohol, nucleophilic substitution can occur, and bromine atoms are replaced by alkoxy groups to generate corresponding ether compounds.
Fluorine atoms are highly electronegative, which has a significant impact on the electron cloud of the benzene ring, reducing the electron cloud density of the benzene ring and increasing the difficulty of electrophilic substitution reaction. However, due to its small radius, it is stable to connect with the benzene ring and can enhance the molecular chemical stability.
Nitro is a strong electron-absorbing group, which not only greatly reduces the electron cloud density of the benzene ring, but also reduces the electron cloud density of the adjacent and para-sites of the benzene ring more than the meta-site. This characteristic makes the electrophilic substitution reaction mainly occur in the meta-site. Moreover, nitro can participate in the reduction reaction. Under suitable conditions, if iron and hydrochloric acid are used as reducing agents, nitro can be reduced to amino groups, and new compounds
Trifluoromethyl is also a strong electron-absorbing group, which has a great influence on the electron cloud density of the benzene ring and can change the molecular polarity and fat solubility. Due to the existence of trifluoromethyl, the lipid solubility of the compound is enhanced. In some organic synthesis, this property can be used to carry out phase transfer catalytic reactions, etc., to promote the reaction.
This compound as a whole is active in chemical properties due to the existence of many electron-absorbing groups. It is widely used in the field of organic synthesis and can be used as a key intermediate for the preparation of various organic compounds such as drugs, pesticides and functional materials.
What are the main uses of 3-Bromo-4-Fluoro-5-Nitrobenzotrifluoride?
3-Bromo-4-fluoro-5-nitrotrifluorotoluene has a wide range of uses. In the field of pharmaceutical synthesis, it can be a key intermediate. For example, when creating a specific anti-cancer drug, with its unique chemical structure, it can participate in the construction of the core pharmacoactive group, through a series of delicate reactions, so that the drug can accurately act on the target of cancer cells, or block the proliferation signal pathway of cancer cells, or induce cancer cell apoptosis, helping to overcome cancer diseases.
In the field of pesticide research and development, it also has important value. Using it as a starting material, efficient insecticides can be derived. By interfering with the physiological functions of the nervous system and respiratory system of pests, such pesticides can achieve efficient killing of pests, and can ensure a bumper agricultural harvest while minimizing the adverse impact on the environment and maintaining ecological balance.
In the field of materials science, 3-bromo-4-fluoro-5-nitrotrifluorotoluene is also available. When used in the synthesis of special polymer materials, the materials can be endowed with characteristics such as excellent heat resistance and chemical corrosion resistance. These high-performance materials are widely used in cutting-edge fields such as aerospace and electronic information. For parts of aerospace vehicles, they need to withstand extreme temperatures and complex chemical environments. The components made of this material can meet strict requirements and ensure the safety of navigation and the stable operation of equipment.
What is 3-Bromo-4-Fluoro-5-Nitrobenzotrifluoride synthesis method?
The synthesis of 3-bromo-4-fluoro-5-nitrotrifluorotoluene is a key research in the field of organic synthesis. To make this substance, there are two common paths.
First, benzene derivatives containing specific substituents are used as starting materials. If 3-bromo-4-fluorobenzoic acid is used as the starting material, the carboxyl group is first converted into a suitable leaving group, such as acyl chloride, which can be obtained by co-heating with dichlorosulfoxide. Then, through nucleophilic substitution, trifluoromethyl is introduced. For example, trifluoromethylation reagents, such as trifluoromethyl copper lithium reagents, react under strict conditions of low temperature and anhydrous and oxygen-free to generate corresponding trifluoromethylation products. Next, with a suitable nitrifying agent, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid, the product is nitrified under temperature control conditions, and a nitro group is introduced at a specific position in the benzene ring to obtain 3-bromo-4-fluoro-5-nitrotrifluorotoluene.
Second, using 4-fluoro-5-nitrotrifluorotoluene as the starting material, bromine atoms are introduced through a bromination reaction. Liquid bromine can be selected, and the reaction is heated in the presence of a suitable catalyst, such as iron powder or iron tribromide. In this reaction, the catalyst promotes the polarization of bromine molecules, enhances its electrophilic activity, and then selectively brominates at specific positions in the benzene ring, resulting in the final target product 3-bromo-4-fluoro-5-nitrotrifluorotoluene.
During the synthesis process, the reaction conditions need to be carefully controlled, and the temperature, reaction time, and reagent dosage are all critical. The separation and purification of the product cannot be ignored. Column chromatography, recrystallization, etc. are commonly used to obtain high-purity 3-bromo-4-fluoro-5-nitrotrifluorotoluene.
What is the market price of 3-Bromo-4-Fluoro-5-Nitrobenzotrifluoride?
I don't know the market price of 3 - Bromo - 4 - Fluoro - 5 - Nitrobenzotrifluoride. The price of this compound often varies for a variety of reasons, such as purity, yield, market supply and demand, and suppliers.
If you ask for its price, you can check it in detail on the chemical product trading platform. Such platforms gather many suppliers, each with its price, which can be compared. However, the purity of the products supplied by different suppliers may vary, and the price varies accordingly. High purity products are often expensive; low purity products are slightly cheaper.
Or you can contact the chemical raw material supplier directly. Inform the detailed specifications of the required product and ask them for a quotation. Suppliers may offer different price discounts depending on the purchase volume. When purchasing in large quantities, the unit price can often be reduced.
And the supply and demand situation in the chemical market also has a great impact on the price. If demand is strong and supply is low, the price will rise; if supply exceeds demand, the price may decline.
In short, to know the accurate market price of 3 - Bromo - 4 - Fluoro - 5 - Nitrobenzotrifluoride, it is necessary to check in detail through multiple channels and comprehensively consider all factors to obtain more accurate price information.
What are the precautions in storage and transportation of 3-Bromo-4-Fluoro-5-Nitrobenzotrifluoride?
3-Bromo-4-fluoro-5-nitrotrifluorotoluene is an organic compound, and many matters need to be paid attention to during storage and transportation.
It is chemically active and sensitive to heat and light. When storing, keep it in a cool, dry and well-ventilated place. If heated, its stability can be easily damaged or cause dangerous reactions, so it is the first thing to keep away from heat and fire sources. Warehouse temperature should be maintained within a certain range, and must not be too high to prevent accidents.
Because it is easy to decompose when exposed to light, it should be stored in containers or warehouses protected from light, such as dark glass bottles or opaque metal containers, which can effectively block light and keep its chemical properties stable.
This compound may be toxic and corrosive, and must be strictly protected during operation and transportation. Transport personnel should wear professional protective equipment, such as protective clothing, gloves and goggles, to prevent physical injury from contact. Packaging must be tight and reliable, and corrosion-resistant materials should be selected to ensure that there is no risk of leakage during transportation. If it leaks, it will be toxic and corrosive or endanger the environment and personnel safety, so the tightness of packaging is crucial.
Furthermore, severe vibration and collision should be avoided during transportation. Because its structure contains active groups, strong vibration or collision or chemical reaction, or even explosion. Transportation vehicles need to run smoothly, and the loading and unloading process should also be handled with caution.
Storage and transportation of 3-bromo-4-fluoro-5-nitrotrifluorotoluene requires comprehensive consideration in terms of temperature, light, protection and shock resistance to ensure personnel safety and item stability.