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What are the main uses of 3-Borono-5-Chlorobenzotrifluoride?
3-Boron-5-chlorotrifluorotoluene, this substance is very important in the field of organic synthesis. First, it is often a key building block for the construction of complex organic molecules. Because of its boron group and chlorine atoms, it can undergo various organic reactions, such as Suzuki coupling reaction, coupling with other organic halides or electrophilic reagents, thereby expanding the carbon-carbon bond to build complex aromatic derivatives, which is of great value in the fields of medicinal chemistry and materials science.
In drug development, the Suzuki coupling reaction, using 3-boron-5-chlorotrifluorotoluene as the starting material, can construct a molecular skeleton with specific biological activities, laying the foundation for the creation of new drugs. In the field of materials science, organic materials with special photoelectric properties can also be prepared by this reaction, such as organic Light Emitting Diode (OLED) materials, organic photovoltaic materials, etc., which are widely used in display technology and energy fields.
Second, it also plays an important role in functional group conversion reactions. Boron groups can be converted into a variety of other functional groups, such as hydroxyl groups, amino groups, etc., while chlorine atoms can introduce different groups through nucleophilic substitution reactions, and then modify the molecular structure finely to meet specific needs.
In summary, 3-boryl-5-chlorotrifluorotoluene, with its unique structure and reactivity, is an indispensable and important compound in many fields such as organic synthesis, drug research and development, and material preparation. It plays a key role in promoting the development of various fields.
What are 3-Borono-5-Chlorobenzotrifluoride synthesis methods?
There are several common methods for the synthesis of 3-boryl-5-chlorotrifluorotoluene.
First, halogenated aromatics are used as starting materials. First, halogenated aromatics containing chlorine and trifluoromethyl are taken, often using transition metals such as palladium (Pd) as catalysts, with appropriate ligands, in a specific solvent, with boron reagents, such as bisphenyl alcohol borate (Bis (pinacolato) diboron). This reaction condition is quite critical, and the temperature needs to be strictly controlled, usually between tens and hundreds of degrees Celsius. For example, in a certain experiment, toluene is used as a solvent and reacted at 80 ° C. The palladium catalyst is proportionally adapted to the ligand. After several hours of reaction, the halogen atom of the halogenated aromatic hydrocarbon can be replaced by boron group to obtain the target product 3-boronyl-5-chlorotrifluorotoluene.
Second, start from the aromatic compound containing boron. Select a suitable boron-containing aromatic substrate and introduce chlorine and trifluoromethyl through a specific substitution reaction. For example, benzene derivatives replaced by borate esters, under the action of suitable halogenating agents, first introduce chlorine atoms, and then introduce trifluoromethyl through a series of reactions. In the halogenation step, it is crucial to choose the appropriate halogenating agent and reaction conditions, and the reaction of introducing trifluoromethyl often requires specific nucleophiles and alkaline environments, and each step of the reaction needs to be carefully regulated to effectively synthesize the target product.
Third, react with aromatic hydrocarbons containing boron and chlorine with trifluoromethylating reagents. React aromatic hydrocarbons containing boron and chlorine with specific trifluoromethylating reagents under suitable catalysts and reaction conditions. In this process, catalyst activity, reaction temperature and time, and solvent type all affect the reaction process and product yield. If a new type of metal catalyst is selected, the selectivity and efficiency of the reaction can be improved under the optimized reaction conditions, and the effective synthesis of 3-boron-5-chlorotrifluorotoluene can be realized.
What are the physical properties of 3-Borono-5-Chlorobenzotrifluoride?
3-Boron-5-chlorotrifluorotoluene is one of the organic compounds. It has unique physical properties and is important in the field of chemistry.
Looking at its appearance, at room temperature, it is often colorless to light yellow liquid, clear and transparent, which is convenient for many chemical operations and reactions. In the process of chemical synthesis, due to its special structure, it can participate in various reactions and serve as a key intermediate to assist in the construction of complex organic molecules.
When it comes to boiling point, it is about a certain temperature range. This property is related to the method of separation and purification. The boiling point is the critical temperature at which a substance changes from liquid to gaseous state. In separation operations such as distillation, it can be separated from other substances to obtain pure products.
Melting point is also one of its important physical properties. The specific melting point, or in a certain temperature range, is very important for the identification and characterization of the compound. Determination of the melting point can help chemists identify its purity and crystal form and other characteristics.
In terms of solubility, 3-boro-5-chlorotrifluorotoluene has a certain solubility in common organic solvents, such as dichloromethane, chloroform, etc. This solubility makes it easy to disperse and mix in solution reactions, and fully contact with the reactants to promote the efficient occurrence of the reaction.
Density is also a consideration. Its density has a specific value. In chemical production and experimental operation, it is related to material measurement and reaction system ratio. Precisely grasping the density can ensure that the reaction proceeds as expected and improve the quality and yield of the product.
In addition, its stability cannot be ignored. Under normal storage and operating conditions, it has certain stability, but under specific conditions, such as high temperature, strong acid and alkali, etc., it may cause chemical reactions and cause structural changes. Therefore, when storing and using, appropriate protection and operation measures should be taken according to its properties to ensure that its properties remain unchanged, and it is used safely and efficiently.
What are the chemical properties of 3-Borono-5-Chlorobenzotrifluoride?
3 - Borono - 5 - Chlorobenzotrifluoride is an organic compound with unique chemical properties. In this compound, the boron group (-B (OH) ³) is connected to the 5-chloro-trifluoromethylphenyl group.
The boron group is electrophilic, because the outer electron of the boron atom does not reach the octet structure, it has a tendency to accept electron pairs. This property enables the compound to participate in a variety of organic reactions, such as the Suzuki-Miyaura coupling reaction. In this reaction, the boron group can be coupled with halogenated aromatics or alkenes under the action of palladium catalysts and bases to form carbon-carbon bonds, thereby constructing complex organic molecular structures, which are widely used in drug synthesis and materials science.
5 -chlorine atoms on the benzene ring also affect the properties of compounds. Chlorine atoms have an electron-absorbing effect, which reduces the electron cloud density of the benzene ring and changes the activity of the electrophilic substitution reaction of the benzene ring. In the electrophilic substitution reaction, the adjacent and para-localization effects of chlorine atoms can guide the reaction check point and make the reaction selectively occur at a specific location.
Trifluoromethyl (-CF 🥰) is a strong electron-absorbing group, which significantly changes the electron cloud distribution of the benzene ring and enhances the stability and lipid solubility of the compound. The highly electronegative fluorine atoms give trifluoromethyl a unique physical and chemical properties, such as enhancing the thermal stability, chemical stability and biological activity of the compound. In drug development, the introduction of trifluoromethyl can often improve the metabolic stability, membrane permeability and binding ability of drugs to targets.
In summary, 3-Borono-5-Chlorobenzotrifluoride exhibits diverse chemical properties due to the synergistic effect of boron groups, chlorine atoms and trifluoromethyl, and has important application value in organic synthesis and related fields.
What is the price range of 3-Borono-5-Chlorobenzotrifluoride in the market?
The price range of 3-boron-5-chlorotrifluorotoluene in the market is difficult to determine. The price of this product can often be influenced by many changes, such as the supply and demand of materials, the method of production, the quality of quality, the number of purchases, and even the momentum of the city.
Looking at the market conditions in the past, the price of this product, if the purchase quantity is rare, only needs a little for research and testing, and the price per gram may reach tens of gold, or even more than 100 gold. Due to the small purchase demand, the supplier needs to worry about the cost of material preparation, delivery, etc., resulting in high unit value.
However, if the buyer needs a large quantity, the price should drop sharply in terms of industrial usage. Since the batch is large, the living can enjoy the benefits of scale, and the cost is diluted, and the price per gram may fall to the realm of several gold.
And the supply and demand of materials have a deep impact on the price. If there is an oversupply, the living will reduce the price to compete for the market in order to sell their goods; if the demand is too high, the scarcity will be expensive, and the price will rise. The new and old methods, the fine and the rough quality, are also related to the price. The new method may reduce the cost and the price, and the price of high-quality products may be slightly higher.
Therefore, in order to know the exact price of 3-boryl-5-chlorotrifluorotoluene, it is necessary to observe the current market situation and consult with the supplier in detail before obtaining the accurate value.