3 Acetamidobenzotrifluoride
Fluoride
3-Acetamidobenzotrifluoride
Chemical Formula C9H8F3NO
Molecular Weight 203.16
Appearance White to off - white solid
Melting Point 79 - 82 °C
Boiling Point 145 - 147 °C (12 mmHg)
Density 1.314 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Flash Point 128 °C
Stability Stable under normal conditions
FAQ

What are the main uses of 3-Acetamidobenzotrifluoride?

3-Acetaminotrifluorotoluene has a wide range of uses. In the field of medicine, this is a key intermediate. Due to the unique electronic effect and fat solubility of trifluoromethyl, it can significantly improve the physical and chemical properties of drug molecules, such as enhancing their absorption, distribution, metabolism and excretion characteristics in living organisms. By introducing 3-acetaminotrifluorotoluene as a structural unit, drugs with specific pharmacological activities can be created to deal with various diseases.

In the field of pesticides, it also plays an important role. Due to its special chemical structure, pesticides are endowed with better biological activity and environmental adaptability. It can be used as a key raw material for the synthesis of new pesticides, which can help to develop high-efficiency, low-toxicity and environmentally friendly pesticide varieties, thereby effectively preventing and controlling crop diseases and insect pests, and improving crop yield and quality.

In the field of materials science, 3-acetamido-trifluorotoluene can be used to synthesize special polymer materials. Because it contains trifluoromethyl, it can endow materials with unique properties such as excellent heat resistance, chemical stability and weather resistance. Such materials may be used in high-end fields such as aerospace, electronics and electrical appliances to meet the strict requirements of materials in specific environments.

In addition, in the field of organic synthetic chemistry, 3-acetamidotrifluorotoluene is an important synthetic building block, providing an effective way for the construction of more complex organic compounds. Chemists can perform various chemical reactions based on this, expand the structural diversity of organic compounds, and lay a solid foundation for new drug development and new material creation.

What are the physical properties of 3-Acetamidobenzotrifluoride?

3-Acetaminobenzo trifluoride, this is an organic compound. Its physical properties are quite important and are related to many practical applications.

Under normal temperature and pressure, it often appears as a white to light yellow crystalline powder with regular morphology and uniform texture. It is easy to handle and measure in many chemical experiments and industrial production.

When it comes to melting point, it is about 102-104 ° C. This melting point characteristic is of great significance. In the process of purification and identification, its purity can be determined based on this. It also provides a key reference for setting relevant chemical reaction conditions. When the temperature reaches this range, the compound will change from solid to liquid state, and the intermolecular forces will change, creating a suitable physical environment for subsequent reactions.

The boiling point is usually around 322.2 ° C. The boiling point reflects the strength of the intermolecular forces, and a higher boiling point indicates that the intermolecular interactions are strong. In separation operations such as distillation, this boiling point data is the key basis for precise temperature control and effective separation.

Solubility is also an important property. It is soluble in some organic solvents, such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. In dichloromethane, by virtue of the principle of similar miscibility, the molecules can be uniformly dispersed to form a stable solution, which provides a homogeneous environment for the reaction in organic synthesis, which is conducive to the smooth progress of the reaction. However, its solubility in water is very small, which is due to the hydrophobic groups such as trifluoromethyl contained in the molecular structure, which makes it difficult to form effective interactions with water molecules.

In terms of density, it is about 1.34 g/cm ³. Density, as an inherent property of matter, is crucial for the conversion of volume and mass during storage, transportation and mixing, ensuring the accuracy of operation.

In addition, 3-acetaminobenzotrifluoride has certain stability, but under specific conditions, such as high temperature, strong acid and alkali environment, chemical reactions may occur and the molecular structure may change. Therefore, when storing and using, it is necessary to properly control the environmental conditions according to its physical properties to ensure its quality and performance.

What is 3-Acetamidobenzotrifluoride chemical synthesis method?

To prepare 3-acetaminotrifluorotoluene, the following method can be followed.

First take m-aminotrifluorotoluene as the starting material. This raw material reacts with acetic anhydride under suitable reaction conditions. Acetoanhydride is an acylation reagent that acylates with the amino group in m-aminotrifluorotoluene. During the reaction, pay attention to the reaction temperature, time and proportion of the reactants.

Place m-aminotrifluorotoluene and an appropriate amount of acetic anhydride in a reaction vessel and dissolve it in a suitable solvent. The usual inert organic solvent such as dichloromethane can fully mix the reactants and facilitate the reaction. Then, under a certain temperature range, such as room temperature to moderate heating (about 40-60 ° C), the reaction is stirred for a period of time, about several hours to ten hours, so that the reaction is fully completed.

After the reaction is completed, post-treatment is required. By common separation and purification methods, such as adding water to quench excess acetic anhydride, then extracting the product with an organic solvent, combining the organic phases, drying with a desiccant such as anhydrous sodium sulfate, filtering and removing the desiccant, and then distilling under reduced pressure to remove the solvent to obtain a crude product. The crude product was further refined by column chromatography and other methods, and a suitable eluent was selected. According to the distribution difference between the product and the impurities in the stationary phase and the mobile phase, the product and the impurities were separated, and finally pure 3-acetamidotrifluorotoluene was obtained. This synthesis method has been verified by many experiments, and can stabilize the preparation of the target product. The operation is relatively easy, and the yield is acceptable, which is suitable for the preparation of laboratories and a certain scale.

3-Acetamidobenzotrifluoride What are the precautions during storage and transportation?

3-Acetaminotrifluorotoluene, when storing and transporting, all kinds of things should be paid attention to.

Bearing the brunt, this is a chemical, whether it is dangerous or not, it must be clarified in detail. If it is flammable, explosive, and toxic, the storage place must be strictly selected. It is advisable to choose a well-ventilated, cool and dry place, away from fire and heat sources, to prevent unexpected changes. And it must be separated from oxidants, acids, bases, etc., to avoid mutual reaction and cause harm.

Furthermore, the tight packaging is crucial. If the packaging is not good, the risk of leakage will increase greatly, which will not only damage the goods, but also endanger the surrounding environment and personal safety. Therefore, the packaging materials should be corrosion-resistant, pressure-resistant, and sealed without gaps.

When transporting, the carrier must have the corresponding qualifications, and the employees must also be familiar with the characteristics of this chemical and emergency disposal methods. When driving on the way, keep the words stable to avoid bumps, prevent collisions, and ensure its stability.

In addition, in the place of storage and transportation, warning signs are indispensable. Clearly state its characteristics, hazards, and emergency measures, so that everyone can be prepared. Once something happens, it can be disposed of quickly according to the signs, and the damage can be minimized.

Also, relevant records must be detailed. When to store, when to ship, and the quantity and geometry must be recorded for retrospective inquiry and in accordance with regulatory requirements.

Overall, the storage and transportation of 3-acetaminotrifluorotoluene are interlinked, and they are all related to safety and must not be ignored.

What is the market outlook for 3-Acetamidobenzotrifluoride?

In today's chemical market, the situation of 3-acetaminobenzotrifluoride is quite impressive. This substance has a wide range of applications in the fields of medicine, pesticides and materials.

In the field of medicine, it is often the key intermediate for the synthesis of specific drugs. Today, the demand for high-efficiency, low-toxicity and targeted new drugs is increasing. Due to its unique chemical structure, 3-acetaminobenzotrifluoride can endow the synthesized drugs with better biological activity and pharmacokinetic properties, so the demand for new drugs is on the rise steadily in the process of new drug development.

In the field of pesticides, with the deepening of green environmental protection concepts, the demand for new, efficient and low-residue pesticides has surged. 3-Acetaminobenzotrifluoride can be used to create pesticides with novel mechanisms of action, helping to improve the yield and quality of crops, and resist the invasion of pests and diseases. It also has broad market prospects in the pesticide industry.

In terms of materials, with the vigorous development of high-tech industries such as electronics and optics, the demand for high-performance materials is also rising. 3-Acetaminobenzotrifluoride can be used as a raw material to participate in the synthesis of polymer materials with special properties, such as high temperature resistance, chemical corrosion resistance and excellent optical properties, to meet the special needs of different fields.

Looking at its market supply, with the expansion of its application field, many chemical companies have paid attention to this and have increased investment in R & D and production. However, its synthesis process may have certain difficulties and cost considerations, and some high-end products may still rely on imports. Market competition is becoming increasingly fierce, and enterprises need to make efforts in technological innovation, product quality and cost control in order to gain a head start in the market.

Consumers are also paying more and more attention to environmental protection and product quality, prompting manufacturers to follow stricter standards and continuously optimize production processes to meet the diverse needs of the market. To sum up, 3-acetamidobenzotrifluoride has both opportunities and challenges in the current market, with broad prospects but also needs to deal with many problems.