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What are the main uses of 2-Methoxy-5-Nitrobenzotrifluoride?
2-Methoxy-5-nitrotrifluorotoluene, which has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Due to its special chemical structure, it can be introduced into the molecular structure of the drug through a series of reactions to help build compounds with specific pharmacological activities. For example, some innovative drug development targeting specific disease targets, this compound may play an important role in the synthesis route. Through clever chemical transformation, it lays the foundation for the creation of new drugs with high efficiency and low toxicity.
In the field of pesticide chemistry, it also plays an important role. It can be used as a starting material for the synthesis of new pesticides, and its structure endows pesticides with unique properties, such as enhancing the poisoning effect on pests, improving the prevention and control ability of specific agricultural crop diseases, and having suitable stability and degradation characteristics in the environment, in order to meet the development needs of modern green pesticides.
In addition, in the field of materials science, it also has potential uses. Or it can participate in the synthesis of functional materials, endowing materials with special optical and electrical properties, opening up new directions for the research and development of new materials. Because of its combination of trifluoromethyl, methoxy and nitro groups, it can significantly affect the physical and chemical properties of materials, so that materials show unique advantages in optoelectronic devices, polymer material modification, etc. Overall, 2-methoxy-5-nitrotrifluorotoluene is of great value in many fields, providing key support for technological innovation and new product creation in various fields.
What are the physical properties of 2-Methoxy-5-Nitrobenzotrifluoride?
2-Methoxy-5-nitrotrifluorotoluene is one of the organic compounds. Its physical properties are unique, let me tell them one by one.
Looking at its appearance, under room temperature and pressure, it is mostly a light yellow to light brown liquid, clear and with a specific luster, which is its visual characterization.
Smell it, there is a specific smell emitted, but this smell is not a pungent and intolerable genus, but it also has a certain degree of identification, which is one of its major characteristics.
When talking about the melting point, it is about -10 ° C to -5 ° C, and it may fluctuate slightly due to the preparation process and purity. The lower melting point allows this substance to remain liquid at relatively low temperatures. The boiling point of
is in the range of 240 ° C to 245 ° C, indicating that it needs a higher temperature to change from liquid to gaseous state. This boiling point characteristic is crucial for the control of separation, purification and related chemical reaction processes.
In terms of density, it is about 1.45 - 1.50 g/cm ³, which is heavier than water. If it is mixed with water, it will sink underwater.
Solubility is also an important physical property. This substance exhibits good solubility in organic solvents such as ethanol, ether, and dichloromethane, and can be miscible with many organic solvents. However, in water, the solubility is very small and almost insoluble. Due to the existence of fluorine atoms and nitro and methoxy groups in the molecular structure, it is difficult to form effective interactions with water molecules.
The vapor pressure is relatively low at room temperature, indicating that its volatilization tendency is weak. This characteristic is related to the stability and safety of the substance during storage and use, making it difficult to evaporate quickly and escape into the air.
The physical properties of 2-methoxy-5-nitrotrifluorotoluene play a key role in restricting and guiding its application in organic synthesis, medicine and chemical industry.
Is 2-Methoxy-5-Nitrobenzotrifluoride chemically stable?
The stability of the chemical properties of 2-methoxy-5-nitrotrifluorotoluene is related to many aspects.
From the structural point of view, methoxy (-OCH
) is the power supply group, which is above the benzene ring and can affect the distribution of electron clouds. Nitro (-NO) is a strong electron-withdrawing group with a strong electron-pulling effect. Trifluoromethyl (-CF) is also a strong electron-withdrawing group because it contains fluorine atoms with extremely high electronegativity.
These three types of groups coexist in the benzene ring, resulting in uneven distribution of electron cloud density in the benzene ring. The electron cloud density of the benzene ring is relatively increased by the methoxy group, while the electron cloud density of the benzene ring is reduced by the nitro group and the trifluoromethyl group. The interaction of such electronic effects has a great impact on the stability of the compound.
In chemical reactions, due to the strong electron-absorbing properties of nitro and trifluoromethyl groups, the electron cloud density of the benzene ring decreases, making it difficult for electrophilic substitution reactions to occur, which seems to improve its stability in specific electrophilic environments. However, the existence of nitro groups makes the benzene ring prone to reduction reactions. If a suitable reducing agent is encountered, the nitro group may be reduced, resulting in structural changes and impaired stability.
In terms of thermal stability, if there is no external chemical reagent action, only affected by heat, the structure of the compound may remain stable in the general temperature range. However, if the temperature is too high, some chemical bonds may break due to sufficient energy, triggering decomposition reactions and reducing stability.
In an acid-base environment, due to the reactivity of the groups it contains with acid and base, if it is in a strong acid or strong base environment, or reacts such as hydrolysis and substitution occur, its stability is affected. In a neutral and mild environment, the stability is relatively higher.
In summary, the chemical stability of 2-methoxy-5-nitrotrifluorotoluene is non-absolute and varies according to specific external conditions, such as temperature, chemical reaction reagents, acid-base environment, etc.
What are 2-Methoxy-5-Nitrobenzotrifluoride synthesis methods?
The synthesis methods of 2-methoxy-5-nitrotrifluorotoluene are as follows.
First, the aromatic compound containing methoxy group is used as the starting material. First, the raw material and appropriate nitrifying reagents, such as the mixed acid system of nitric acid and sulfuric acid, are nitrified at a specific temperature and reaction time. During this process, the reaction conditions need to be carefully controlled. Due to high temperature or long reaction time, it is easy to cause excessive nitrification and generate unnecessary by-products. After the successful introduction of nitro groups, trifluoromethyl is introduced. A suitable trifluoromethylation reagent, such as trifluoromethyl halide, can be selected to react in the presence of a catalyst, and after several steps of conversion, the final product is 2-methoxy-5-nitrotrifluorotoluene.
Second, an aromatic compound containing trifluoromethyl can also be used as a starting material. First, it is methoxylated. The nucleophilic substitution reaction between alkoxides and halogenated aromatics can be used, and suitable alkoxides and reaction solvents, such as potassium carbonate and sodium methoxide, can be selected. In a suitable organic solvent such as N, N-dimethylformamide (DMF), it reacts with halogenated aromatics and introduces methoxy groups. Then the nitration reaction is carried out. By carefully adjusting the nitration reaction conditions, such as controlling the ratio of nitric acid to sulfuric acid, reaction temperature and time, nitro groups are precisely introduced to synthesize 2-methoxy-5-nitrotrifluorotoluene.
Third, it can also be considered to achieve multi-step functional group transformation based on compounds with partial target structures. For example, compounds with similar structures but need further modification are prepared first, and the complete structure of the target molecule is gradually constructed through a series of reactions such as halogenation, substitution, and oxidation-reduction. In each step of the reaction, the reaction conditions, the amount of reagents and the purity must be strictly controlled to improve the yield and selectivity of the reaction, and finally 2-methoxy-5-nitrotrifluorotoluene is successfully synthesized.
What is the price range of 2-Methoxy-5-Nitrobenzotrifluoride in the market?
Nowadays, the market is complex and the prices are variable. It is not easy to know the price range of 2-methoxy-5-nitrotrifluorotoluene in the market. However, you can make a brief exploration method for reference.
In the past, if you want to find the price of various things, you often rely on merchants and traders to ask each other and exchange market information. Today, it is not the case. The Internet is prosperous and the information is convenient. You can search for the name of this thing on various platforms of chemical trading. Such platforms gather all kinds of chemical materials, and many merchants list the goods with their prices attached. High or low, depending on the material, quantity, and origin.
Or someone who has consulted a chemical broker, who has been involved in this trip for a long time, dealing between producers and buyers, familiar with market changes, and able to say the approximate price of this product. However, what he said is only a temporary situation, the market is turbulent, and the price changes with supply and demand and seasons.
There are also homes that produce this product, so you can ask directly. Producer pricing is related to cost, profit, market competition, and the price offered may be used as a benchmark. However, it also takes into account the state of the market, so it is not static.
Although it has tried every means, it is difficult to determine the exact price. In the chemical industry market, the price of raw materials has risen and fallen, and the tax policy has become easier. It is difficult to give an exact range if the price of 2-methoxy-5-nitrotrifluorotoluene fluctuates between hundreds of yuan per kilogram and thousands of yuan per kilogram. It is necessary to investigate in detail according to the current market conditions to obtain a more accurate price.