What are the main uses of 2-Fluoro-3-bromobenzotrifluoride?

2-Fluoro-3-bromotrifluorotoluene has a wide range of uses. In the field of pharmaceutical synthesis, it can be called a crucial intermediate. Due to the unique chemical properties of fluorine, bromine and trifluoromethyl, it can be ingeniously introduced into the molecular structure of various drugs through delicate organic synthesis reactions, thereby significantly optimizing the many properties of drugs. For example, the introduction of fluorine atoms can often enhance the binding ability of drugs and targets, just like adding a solid bond between drugs and targets, enhancing the activity of drugs; the presence of bromine atoms can adjust the lipid solubility and metabolic stability of drugs, just like putting a protective armor on drugs, so that they can play a more lasting role in the body. In the preparation of many antibacterial, anti-inflammatory and neurological drugs, 2-fluoro-3-bromotrifluorotoluene is frequently used as the starting material. After multiple carefully designed reactions, the desired drug is finally obtained.

In the field of materials science, 2-fluoro-3-bromotrifluorotoluene also occupies an important place. Because of its trifluoromethyl content, it imparts excellent chemical stability and hydrophobicity to the molecule. Therefore, it is often used as a key monomer or modifier in the preparation of high-performance fluoropolymer materials. Through polymerization, its unique structure can be integrated into the main chain or side chain of the polymer, resulting in excellent properties such as chemical resistance, low surface energy and good thermal stability. These materials are widely used in high-end fields such as aerospace and electronics industries. For example, in the aerospace field, some parts used in the manufacture of aircraft need to have strong corrosion resistance and thermal stability, and polymer materials derived from 2-fluoro-3-bromotrifluorotoluene can meet such stringent requirements; in the electronics industry, it can be used to make special coatings to protect electronic components from external environmental erosion.

Furthermore, in the synthesis of pesticides, 2-fluoro-3-bromotrifluorotoluene also plays an indispensable role. Its special chemical structure can give pesticides unique biological activities. Through rational molecular design and synthesis, pesticide molecules based on them can effectively kill or inhibit specific pests or weeds, and because of their structural characteristics, some pesticides also have the advantages of environmental friendliness, which can degrade quickly in the environment, reduce the long-term impact on the ecological environment, and contribute to the sustainable development of agriculture.

What are the physical properties of 2-Fluoro-3-bromobenzotrifluoride?

2-Fluoro-3-bromotrifluorotoluene is an organic compound. Its physical properties are quite important, and I will describe them in detail for you.

First of all, its appearance, under normal temperature and pressure, 2-fluoro-3-bromotrifluorotoluene is often colorless to light yellow transparent liquid. It is clear in appearance and has a unique luster flow.

and its boiling point. The boiling point of this compound is about 150 ℃ - 160 ℃. The boiling point is the critical temperature at which a substance changes from liquid to gaseous state. At this temperature, the molecule of 2-fluoro-3-bromotrifluorotoluene obtains enough energy to break free from the liquid phase and escape into the gas phase.

And the melting point is roughly around -50 ° C. The melting point is the temperature at which a substance changes from a solid state to a liquid state. Below this temperature, 2-fluoro-3-bromotrifluorotoluene will exist in the world as a solid state.

Speaking of density, it is about 1.7 g/cm ³. In terms of density, the mass of the substance per unit volume is also used. This value reflects the degree of density of 2-fluoro-3-bromotrifluorotoluene compared to common substances such as water. Because its density is greater than that of water, if mixed with water, it will sink to the bottom of the water.

In terms of solubility, 2-fluoro-3-bromotrifluorotoluene is insoluble in water, but it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc. This property is due to the interaction force between its molecular structure and the molecules of the organic solvent, so that the two can be uniformly mixed.

Volatility is also one of its important properties. Because it has a certain degree of volatility, it will slowly dissipate into the air at room temperature. Although this process is quiet, it needs to be treated with caution in confined spaces or when stored in large quantities to prevent its concentration from accumulating and causing safety problems.

The physical properties of 2-fluoro-3-bromotrifluorotoluene are such that they are all important points that must be familiar with when studying and applying this compound.

What is 2-Fluoro-3-bromobenzotrifluoride synthesis method?

The preparation of 2-fluoro-3-bromotrifluorotoluene often involves several steps.

The starting material is often selected from a suitable aromatic compound, such as 2-fluorobenzoic acid. In the first step, 2-fluorobenzoic acid can be converted to the corresponding acid chloride. In this process, thionyl chloride ($SOCl_ {2} $) or oxalyl chloride ($ (COCl) _ {2} $) is co-heated with 2-fluorobenzoic acid, and the carboxylic acid group is changed to an acyl chloride. The reaction formula is as follows: 2 dollars -fluorobenzoic acid + SOCl_ {2}\ xrightarrow {\ Delta} 2 -fluorobenzoyl chloride + SO_ {2}\ uparrow + HCl\ uparrow $.

The resulting 2-fluorobenzoyl chloride is subjected to a Hoffman rearrangement reaction. 2-Fluorobenzoyl chloride is treated with bromine and an excess base (e.g. sodium hydroxide $NaOH $). This reaction goes through the intermediate of isocyanate, and finally produces 2-fluorobenzoyl aniline. The reaction formula is: 2 dollars -fluorobenzoyl chloride + Br_ {2} + 4NaOH\ xrightarrow {} 2-fluoroaniline + Na_ {2} CO_ {3} + 2NaBr + 2H_ {2} O $.

Converts 2-fluoroaniline to diazonium salt. 2-Fluorobenzene diazonate can be obtained by treating 2-fluorobenzene with sodium nitrite ($NaNO_ {2} $) and hydrochloric acid ($HCl $) at low temperature (about 0 - 5 ℃). The reaction formula is: 2 dollars -fluorobenzene + NaNO_ {2} + 2HCl\ xrightarrow {0 - 5 ^ {\ circ} C} 2 -fluorobenzene diazonate + NaCl + 2H_ {2} O $. After

, the diazonium salt is subjected to a Sandmeier reaction with cuprous bromide ($CuBr $), and the diazonium group is replaced by a bromine atom to generate 2-bromo-fluorobenzene.

The last step is to introduce trifluoromethyl. The target product 2-fluoro-3-bromotrifluorotoluene can be obtained by reacting with a suitable trifluoromethylation reagent, such as sodium trifluoromethanesulfonate ($CF_ {3} SO_ {2} Na $), catalyzed by a copper salt.

Each step requires attention to the reaction conditions, such as temperature, reactant ratio and catalyst selection, which all have a great influence on the reaction yield and selectivity. In this way, after careful operation in multiple steps, 2-fluoro-3-bromotrifluorotoluene can be obtained.

What 2-Fluoro-3-bromobenzotrifluoride need to pay attention to when storing and transporting

2-Fluoro-3-bromotrifluorotoluene is an organic compound. When storing and transporting it, many matters need to be paid attention to.

First storage conditions. This compound should be stored in a cool, dry and well-ventilated place. Because a cool environment can reduce its volatilization rate, drying can avoid its interaction with water vapor, and good ventilation can prevent the accumulation of harmful gases. If placed in a high temperature or humid place, or cause it to deteriorate, it will affect the quality and performance of use. Furthermore, it is necessary to keep away from fires and heat sources. Because of its flammability, it is dangerous to encounter open flames, hot topics, or cause combustion and explosion, endangering life and property safety.

Second and storage container selection. When using corrosion-resistant materials, such as specific metal or plastic containers. The chemical properties of 2-fluoro-3-bromotrifluorotoluene, or the reaction with certain materials, damage the container and cause the risk of leakage. And the container must be tightly sealed to prevent volatilization and leakage.

As for transportation, there are also many precautions. It is necessary to properly pack according to its dangerous characteristics. Ensure that the packaging is sturdy and can withstand bumps and collisions during transportation. At the same time, the transportation vehicle should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. Transportation personnel should also be professionally trained to be familiar with its characteristics and emergency response methods. During transportation, avoid high temperature periods and densely populated areas to prevent the danger from expanding when accidents occur.

All of these should be taken into account when storing and transporting 2-fluoro-3-bromotrifluorotoluene, so as to ensure its safety, stability and avoid accidents.

What is the market price range for 2-Fluoro-3-bromobenzotrifluoride?

2-Fluoro-3-bromotrifluorotoluene is a fine chemical commonly used in organic synthesis. However, its market price range is difficult to hide, due to the intertwined influence of multiple factors.

First, the cost of raw materials determines the price. The raw materials for the preparation of 2-fluoro-3-bromotrifluorotoluene, such as fluorine-containing, brominated compounds, etc., the price fluctuation is directly related to the price of finished products. If the supply of raw materials is tight, or the price of 2-fluoro-3-bromotrifluorotoluene soars due to unexpected conditions in the origin and a large increase in market demand, the price of 2-fluoro-3-bromotrifluorotoluene will also rise.

Second, the production process is simple and the cost is If the production process is complex, requires multi-step reactions, and requires strict reaction conditions, such as specific temperatures, pressures, catalysts, etc., the production cost will be high, and the product price will also increase accordingly. Advanced and efficient production processes can reduce costs, but the initial investment in R & D and equipment is huge, which will also be reflected in the price.

Third, the market supply and demand situation has a great impact. If there is a period of strong demand for 2-fluoro-3-bromotrifluorotoluene in many industries, such as medicine, pesticides, materials science and other fields, the R & D or production surge, and the supply side is difficult to match quickly, the price will rise; conversely, if the demand is low and the supply is excessive, the price will fall.

Fourth, different suppliers have different pricing strategies. Large suppliers rely on scale effects, good cost control, and price advantages; small suppliers may have slightly higher prices due to factors such as limited output and operating costs. And brand reputation, product quality stability, etc., will also make prices vary.

To sum up, the market price range of 2-fluoro-3-bromotrifluorotoluene is roughly hundreds to thousands of yuan per kilogram. The specific price needs to be determined comprehensively according to the above factors at the time of actual procurement.