What is the main use of 2- (Dimethylamino) Benzotrifluoride?
2-%28Dimethylamino%29Benzotrifluoride is 2- (dimethylamino) trifluorotoluene, which has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate in organic synthesis. In the process of many drug development, it is often used as a starting material or an important structural fragment. Through various chemical reactions, other functional groups can be introduced into its molecules to construct complex compounds with specific pharmacological activities, such as the development of some new antidepressants with unique mechanisms of action. 2- (dimethylamino) trifluorotoluene plays a key role in its synthesis.
In the field of materials science, it also shows important uses. In the preparation of some functional materials, it can be used as a modifier or additive. For example, the addition of some organic optoelectronic materials during synthesis may effectively improve the electronic transport performance and stability of the materials, thereby enhancing the working efficiency and service life of organic optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells.
In the field of pesticide chemistry, 2 - (dimethylamino) trifluorotoluene also occupies a place. It can be used to synthesize pesticide compounds with high insecticidal, bactericidal or herbicidal activities. Due to its special molecular structure, the synthesized pesticides may have unique targets and modes of action, which can show excellent control effects on specific pests and diseases, while reducing the impact on the environment and non-target organisms.
What are the physical properties of 2- (Dimethylamino) Benzotrifluoride
2-%28Dimethylamino%29Benzotrifluoride is 2 - (dimethylamino) trifluorotoluene. The physical properties of this substance are as follows:
Its appearance is usually a colorless to light yellow liquid. Looking at its color, it is like a light yellow light, clear and fluid, placed in a bottle, under the shimmer, shining.
When it comes to smell, it often has a special aromatic smell, but its smell is not rich and tangy, but vaguely lingering, seemingly absent, smelling it is slightly impressive, but not pungent.
As for the boiling point, it is about a specific temperature range. Just as the boiling point of water has its boiling point, this substance also has its own specific temperature node. At this temperature, the liquid will turn into a gaseous state and rise. The value of its boiling point is one of the important characteristics of a substance, which is related to its state transition under different conditions.
Melting point also has a certain value. Like freezing water in a cold winter, this substance will also solidify from liquid to solid at the corresponding low temperature. This melting point temperature allows the material to change its form, like an invisible boundary.
Density is also an important physical property. Its density value is specific, indicating the mass of the substance contained in a unit volume. This property is related to the phenomenon of stratification when it is mixed with other substances. If it is mixed with liquids of different densities and left to stand, or the stratification is clear, or it blends with each other, it is closely related to the density.
Solubility cannot be ignored. In some organic solvents, it can be dissolved, just like a salt melts in water and disperses evenly; in polar solvents such as water, the solubility may be poor, and a two-phase separation state may be formed, which is clearly distinguishable.
2 - (dimethylamino) trifluorotoluene These physical properties are of great significance in many fields such as chemical industry and scientific research, laying the foundation for its application and research.
What are the chemical properties of 2- (Dimethylamino) Benzotrifluoride
2-%28Dimethylamino%29Benzotrifluoride, the Chinese name is 2 - (dimethylamino) trifluorotoluene. The chemical properties of this substance are special.
In terms of its physical properties, it is often lower than normal, or it is a liquid substance. Its external color may be a liquid color to a light color, which has a certain degree of performance. It may be slow in air. It has a special taste, and this taste may be irritating. Its density is low in water, and it is insoluble in water. It is soluble in many soluble molecules, such as ethanol, ether, etc. Due to the principle of similar compatibility, its molecules are not soluble and have a good fit.
In terms of chemical reaction activity, because its molecules contain trifluoromethyl dimethylamino, it exhibits a special chemical property. Trifluoromethyl has a strong absorber effect, which can reduce the density of children on benzene and make benzene more vulnerable to attack. For example, under suitable conditions, it can be chemically substituted for antibodies, and the atom replaces the atom on the benzene atom. And the dimethylamino group is used for the molecular group, which can affect the anti-activity and localization effect of benzene to a certain extent. In some antibodies, the orphan on the nitrogen atom of the dimethylamino group can be reversed, such as the formation of antibodies in the synthesis of acid. In addition, this substance may be used for many important antibodies in the synthesis, such as acetylation antibodies, alkylation antibodies, etc., which are important in the field of synthesis and can be used for many compounds with biological activity or special functions.
What are the synthesis methods of 2- (Dimethylamino) Benzotrifluoride
2-%28Dimethylamino%29Benzotrifluoride is 2 - (dimethylamino) trifluorotoluene, and the synthesis method is as follows:
- ** Using 2-chlorotrifluorotoluene and dimethylamine as raw materials **:
- In an appropriate reaction vessel, 2-chlorotrifluorotoluene is mixed with an aqueous solution of dimethylamine or dimethylamine gas in a certain proportion, and an appropriate amount of acid binding agent, such as potassium carbonate, sodium carbonate, etc. The acid binding agent can neutralize the hydrogen chloride generated by the reaction and promote the positive progress of the reaction.
- With a suitable organic solvent, such as toluene, N, N-dimethylformamide (DMF), etc., as the reaction medium, the reaction is stirred at a certain temperature (usually 60-120 ° C) for several hours. After the reaction is completed, the reaction liquid is cooled, and then the liquid separation operation is carried out to separate the organic phase.
- The organic phase is washed with water and dried successively to remove impurities and moisture. Finally, the product is purified by distillation and other means, and the corresponding fraction is collected to obtain 2 - (dimethylamino) trifluorotoluene.
- ** Using 2 - nitrotrifluorotoluene as the starting material **:
- First dissolve 2 - nitrotrifluorotoluene in an appropriate solvent, such as ethanol, ethyl acetate, etc. In the presence of catalysts (such as palladium carbon, Raney nickel, etc.), introduce hydrogen for reduction reaction, and reduce the nitro group to an amino group to generate 2 - amino trifluorotoluene. This step requires controlling the hydrogen pressure and reaction temperature. Generally, the hydrogen pressure is 1-5 atm, and the temperature is 30-80 ° C. React until hydrogen is no longer absorbed.
- After obtaining 2-aminotrifluorotoluene, mix it with formaldehyde and formic acid, and react at a certain temperature (40-80 ° C). The amino group reacts with formaldehyde and formic acid to generate 2 - (dimethylamino) trifluorotoluene. After the reaction is completed, the product is separated and purified by conventional separation methods such as distillation and extraction, and finally the target product 2 - (dimethylamino) trifluorotoluene is obtained.
2- (Dimethylamino) Benzotrifluoride in the use of what are the precautions
2-%28Dimethylamino%29Benzotrifluoride, it is also necessary to wash with water immediately, and do not delay it.
In addition, it is also necessary to pay attention to the situation and cannot be ignored.
This chemical substance has special properties, and the first thing to pay attention to is its toxicity. It may be harmful to people. If it is accidentally damaged and the skin is damaged, it is recommended to wash it with a lot of water as soon as possible, and it should be treated immediately. If it is in the eyes, it is even more necessary to wash it with water immediately, and do not delay it.
In addition, its durability also needs to be noted. It is better to use it well, so as to prevent it from evaporating in the dense air, causing the air to fall, endangering the human body. And it should not be near open flames or high temperatures to prevent combustion and explosion. Because of its flammability, it is easy to burn in case of fire.
The existence of a fire is also studied.
When operating, you must wear appropriate anti-damage clothing, such as anti-damage clothing, gloves, eyes, etc., to avoid biochemical reactions, causing damage or health hazards.
When operating, you must wear appropriate anti-damage clothing, such as anti-damage clothing, gloves, eyes, etc., to ensure your own safety. And the operator should be safe only if you are familiar with the operation procedures and act according to the rules.
In terms of toxicity, toxicity, storage, and operation, you should be careful and not ignore it to ensure human safety and environmental safety.