What are the main uses of 2-Bromo-6-Fluorobenzotrifluoride?
2-Bromo-6-fluorotrifluorotoluene is an important raw material for organic synthesis. It has a wide range of uses and is often a key intermediate for the creation of new drugs in the field of medicinal chemistry. The molecular structure of the drug is well designed, and the functional groups such as bromine, fluorine and trifluoromethyl contained in 2-bromo-6-fluorotrifluorotoluene can endow the drug with specific biological activity and physicochemical properties. For example, by means of organic synthesis, it can be integrated into the molecular structure of the drug, which can affect the ability of the drug to bind to biological targets, and then regulate the efficacy and selectivity of the drug.
In the field of pesticide chemistry, it is also an important starting material for the preparation of high-efficiency pesticides. Modern pesticides pursue the characteristics of high efficiency, low toxicity and environmental friendliness. The unique chemical structure of 2-bromo-6-fluorotrifluorotoluene can help the development of pesticides with excellent insecticidal, bactericidal or herbicidal properties. Its functional groups can participate in a variety of chemical reactions to build complex and biologically active pesticide molecules, enhance the effect of pesticides on target organisms, and reduce the adverse effects on non-target organisms.
In addition, it also has its application in the field of materials science. For example, when synthesizing special functional polymer materials, it can be introduced into the polymer structure as a monomer or modifier. Due to its fluorine-containing functional group characteristics, it can endow materials with unique properties such as chemical corrosion resistance, low surface energy and excellent thermal stability, thus broadening the application range of materials and playing an important role in high-end fields such as aerospace, electronics and electrical appliances.
In summary, 2-bromo-6-fluorotrifluorotoluene has an indispensable position in many fields such as medicine, pesticides and materials science due to its unique chemical structure, which is of great significance to promote the development of related industries.
What are the physical properties of 2-Bromo-6-Fluorobenzotrifluoride?
2-Bromo-6-fluorotrifluorotoluene is one of the organic compounds. Its physical properties are quite important and are of key significance in the fields of chemical industry and scientific research.
Looking at its properties, under normal temperature and pressure, 2-bromo-6-fluorotrifluorotoluene is mostly colorless to light yellow liquid, with a clear appearance and fluidity. This form is easy to handle and operate in many chemical reactions and industrial processes.
Talking about the melting point, it has been accurately determined to be around -38 ° C. This melting point characteristic allows the compound to maintain its liquid state at lower temperatures. In some reaction systems that require low temperature conditions, it can ensure its good participation and reactivity.
In terms of boiling point, it is usually between 149 and 151 ° C. This boiling point range determines its gasification temperature during heating and provides key parameters for chemical operations such as distillation and separation, which is convenient for effective separation and purification from mixed systems.
The density is about 1.73 g/cm ³, which is relatively dense compared to water. This characteristic affects the distribution and behavior of the compound in the system in processes such as liquid-liquid separation or phase transfer reactions.
Its solubility cannot be ignored. 2-Bromo-6-fluorotrifluorotoluene is insoluble in water, but it can achieve good miscibility with most organic solvents, such as ethanol, ether, dichloromethane, etc. This solubility characteristic provides convenience for its application in organic synthesis reactions. According to the needs of the reaction, a suitable organic solvent can be flexibly selected as the reaction medium to promote the smooth progress of the reaction.
In addition, the physical properties such as vapor pressure and refractive index of 2-bromo-6-fluorotrifluorotoluene also play a role in specific application scenarios. Vapor pressure is related to its existence in the gas phase and the degree of volatilization, while refractive index can be used for purity detection and compound identification. Overall, these physical properties together constitute the basic characteristics of 2-bromo-6-fluorotrifluorotoluene, which has laid a solid foundation for its application in many fields such as chemical industry, medicine, and materials.
What are 2-Bromo-6-Fluorobenzotrifluoride synthesis methods?
There are several common methods for the synthesis of 2-bromo-6-fluorotrifluorotoluene.
First, 2-fluoro-6-methylaniline is used as the starting material. First, 2-fluoro-6-methylaniline is subjected to a diazotization reaction, which is processed at low temperature with sodium nitrite and inorganic acids such as hydrochloric acid or sulfuric acid to form a diazonium salt. This diazonium salt is then reacted with a halogenated cuprous salt such as cuprous bromide to undergo a Sandmeier reaction. The diazonium group can be replaced with a bromine atom to obtain 2-bromo-6-fluorotoluene. Subsequently, antimony trichloride, antimony pentachloride and other catalysts are used to react with anhydrous hydrogen fluoride and chlorine gas to carry out trifluoromethylation of methyl groups, that is, the hydrogen atoms on the methyl group are gradually replaced by fluorine atoms, and finally 2-bromo-6-fluorotrifluorotoluene is obtained.
Second, 2-bromo-6-fluorobenzoic acid is used as the starting material. First, 2-bromo-6-fluorobenzoic acid and methanol are esterified in the presence of concentrated sulfuric acid and other catalysts to generate 2-bromo-6-fluorobenzoic acid methyl ester. Then, using a strong reducing agent such as lithium aluminum hydride, the ester group is reduced to an alcohol hydroxyl group to obtain 2-bromo-6-fluorobenzyl alcohol. After that, under the action of a suitable halogenating agent such as phosphorus tribromide, the alcohol hydroxyl group is replaced with a bromine atom to obtain the corresponding bromine. Finally, under suitable reaction conditions, the bromide on the benzene ring is converted into 2-bromo-6-fluoro-trifluorotoluene by a special fluorinated reagent such as a trifluoromethylating reagent.
Third, 2-bromo-6-fluorobenzaldehyde is used as the raw material. First, 2-bromo-6-fluorobenzaldehyde is reacted with trichloroacetic acid under appropriate alkaline conditions to generate the corresponding glycidyl ester. Then, the glycidyl ester is pyrolyzed, decarboxylated and rearranged to obtain an intermediate product containing trifluoromethyl structure. After appropriate reduction and halogenation steps, 2-bromo-6-fluorotrifluorotoluene is finally obtained.
Each method has its own advantages and disadvantages, and an appropriate synthesis path should be selected according to the actual situation, such as raw material cost, difficulty in reaction conditions, high yield and low yield.
2-Bromo-6-Fluorobenzotrifluoride to pay attention to when storing and transporting
2-Bromo-6-fluorotrifluorotoluene is also a chemical substance. During storage and transportation, many matters need to be paid attention to.
First words storage. This material is more active and should be stored in a cool and ventilated warehouse. If the cover temperature is too high, it may cause its chemical reaction to accelerate, which is dangerous. The warehouse temperature should be controlled within a specific range, and must not be too high. And it needs to be kept away from fire and heat sources. Open flames and hot topics can cause disasters. Because of its flammability, it may be subject to fire or combustion, or even explosion.
Furthermore, it should be stored separately with oxidants and edible chemicals. Oxidants have strong oxidizing properties. When they encounter the substance, they may cause a severe oxidation reaction. Mixed with edible chemicals, if there is a leak, it is easy to contaminate food and endanger humans and animals.
Storage containers are also crucial. Choose the right material to prevent it from reacting with the container and causing leakage. And the container must be sealed to prevent the material from volatilizing, polluting the environment, and preventing it from reacting with substances in the air.
As for transportation, the transportation vehicle must be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During transportation, ensure that the container does not leak, collapse, fall, or damage. Summer transportation should be carried out in the morning and evening to avoid high temperatures, which can easily increase its danger.
Do not mix with contraband substances such as oxidizers during transportation. During driving, drivers and escorts should pay close attention, and if there is any abnormality, they should be disposed of immediately. When loading and unloading, the operation should be handled lightly to prevent damage to the container.
In this way, when storing and transporting 2-bromo-6-fluorotrifluorotoluene, be careful and strictly abide by the regulations to ensure safety.
What is the market price range for 2-Bromo-6-Fluorobenzotrifluoride?
2-Bromo-6-fluorotrifluorotoluene, which is in the chemical market, its price range is quite difficult to determine. Because the price of chemical products is often influenced by various factors, it is constantly changing and difficult to be constant.
The first to bear the brunt is the price of raw materials. If the preparation of various raw materials of 2-bromo-6-fluorotrifluorotoluene, the price will rise or fall, which will lead to fluctuations in the price of finished products. If raw materials are scarce and difficult to find, the price will be high; on the contrary, if the supply is abundant, the price may become easier.
Furthermore, the situation of market supply and demand is also key. If there is a strong demand for 2-bromo-6-fluorotrifluorotoluene in many industries, but the supply is limited, its price will rise; if the market is oversupplied, merchants will reduce their prices to compete for the market in order to sell goods.
Process and cost also affect the price. To prepare this product, if the process is complicated, the energy consumption is huge, and the manpower and material resources are consumed, the cost will be high and the price will be high; if the process is advanced and the cost can be controlled, the price may be lowered.
Regional factors cannot be ignored. In different places, the price varies due to logistics, taxation, market competition, etc. Prosperous commercial port, convenient transportation, fierce competition, price or stable; remote places, logistics costs are high, price or slightly high.
Looking at the past market, its price per kilogram may be between hundreds and thousands of yuan. However, this is only a rough number. Today, it is difficult to determine. To know the exact price, you need to often look at the chemical trading platform, consult industry experts, or consult relevant production and distribution enterprises in detail to get real-time prices.